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Literature summary extracted from

  • Haurand, M.; Flohe, L.
    Kinetic studies on arachidonate 5-lipoxygenase from rat basophilic leukemia cells (1988), Biol. Chem. Hoppe-Seyler, 369, 133-142.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 ATP required Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 arachidonic acid substrate inhibition above 0.045-0.05 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.34 0.182
-
 arachidonic acid
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+ required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 leukemia cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Rattus norvegicus (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.34 7.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.13.11.34 7 9 pH 7.0: 66% of maximal activity, pH 9.0: about 60% of maximal activity Rattus norvegicus