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Literature summary extracted from

  • Denis, D.; Choo, L.Y.; Riendeau, D.
    Activation of 5-lipoxygenase by guanosine 5-O-(3-thiotriphosphate) and other nucleoside phosphorothioates: redox properties of thionucleotide analogs (1989), Arch. Biochem. Biophys., 273, 592-596.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 adenosine stimulates at 0.01 mM or lower Rattus norvegicus
1.13.11.34 Adenosine 5'-O-(2-thiodiphosphate) stimulates at 0.01 mM or lower Rattus norvegicus
1.13.11.34 Guanosine 5'-O-(2-thiodiphosphate) stimulates at 0.01 mM or lower Rattus norvegicus
1.13.11.34 guanosine 5'-O-(3-thiotriphosphate) 10fold stimulation of arachidonic acid oxidation at 0.0005-0.001 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Rattus norvegicus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 leukocyte polymorphonuclear Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Rattus norvegicus (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
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