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Literature summary extracted from

  • Riendeau, D.; Falgueyret, J.P.; Nathaniel, D.J.; Rokach, J.; Ueda, N.; Yamamoto, S.
    Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides (1989), Biochem. Pharmacol., 38, 2313-2321.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 ATP stimulates Sus scrofa
1.13.11.34 phosphatidylcholine stimulates Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 AA861 i.e. 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone, IC50: 0.004-0.01 mM Sus scrofa
1.13.11.34 BW755C CAS: 66000-40-6; IC50: 0.004-0.015 mM Sus scrofa
1.13.11.34 diphenyldisulfide IC50: 0.002-0.005 Sus scrofa
1.13.11.34 L-651,392 i.e. 4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one, + 1 mM NADH, IV50: 0.0003-0.0005 mM Sus scrofa
1.13.11.34 L-651,896 i.e. 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol, IC50: 0.0003-0.0004 mM Sus scrofa
1.13.11.34 L-656,224 IC50: 0.0003-0.0004 mM Sus scrofa
1.13.11.34 N-methyl-2[4-(2,4,6-trimethylphenyl)phenyl]-propenehydroxamic acid IC50: 0.0005 mM Sus scrofa
1.13.11.34 Phenidone IC50: 0.005-0.01 mM Sus scrofa
1.13.11.34 quercetin IC50: 0.0003-0.0005 mM Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+ stimulates Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.34
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 leukocyte
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Sus scrofa (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.0003 0.0005 IC50: 0.0003-0.0005 mM Sus scrofa quercetin
1.13.11.34 0.0003 0.0004 i.e. 2,3-dihydro-6-[3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol, IC50: 0.0003-0.0004 mM Sus scrofa L-651,896
1.13.11.34 0.0003 0.0004 IC50: 0.0003-0.0004 mM Sus scrofa L-656,224
1.13.11.34 0.0005
-
IC50: 0.0005 mM Sus scrofa N-methyl-2[4-(2,4,6-trimethylphenyl)phenyl]-propenehydroxamic acid
1.13.11.34 0.002 0.005 IC50: 0.002-0.005 mM Sus scrofa diphenyldisulfide
1.13.11.34 0.004 0.01 i.e. 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone, IC50: 0.004-0.01 mM Sus scrofa AA861
1.13.11.34 0.004 0.015 IC50: 0.004-0.015 mM Sus scrofa BW755C
1.13.11.34 0.005 0.01 IC50: 0.005-0.01 mM Sus scrofa Phenidone