Literature summary extracted from

Durand, R.; Zenk, M.H.
Enzymes of the homogentisate ring-cleavage pathway in cell suspension cultures of higher plants (1974), FEBS Lett., 39, 218-220.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.5	2,2'-dipyridyl	5 mM, complete inhibition	Drosophyllum lusitanicum

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
1.13.11.5	homogentisate + O2	Phaseolus vulgaris	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Glycine max	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Daucus carota	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Nicotiana sylvestris	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Ruta graveolens	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Melilotus albus	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Coleus scutellarioides	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Agrostemma githago	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Agave toumeyana	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Drosophyllum lusitanicum	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	Pimpinella anisum	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	4-maleylacetoacetate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.5	Agave toumeyana	-	-	-
1.13.11.5	Agrostemma githago	-	-	-
1.13.11.5	Coleus scutellarioides	-	-	-
1.13.11.5	Daucus carota	-	-	-
1.13.11.5	Drosophyllum lusitanicum	-	-	-
1.13.11.5	Glycine max	-	-	-
1.13.11.5	Melilotus albus	-	-	-
1.13.11.5	Nicotiana sylvestris	-	-	-
1.13.11.5	Phaseolus vulgaris	-	var. nanus	-
1.13.11.5	Pimpinella anisum	-	-	-
1.13.11.5	Ruta graveolens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.13.11.5	190fold purification	Drosophyllum lusitanicum
1.13.11.5	partial purification	Phaseolus vulgaris
1.13.11.5	partial purification	Glycine max
1.13.11.5	partial purification	Daucus carota
1.13.11.5	partial purification	Nicotiana sylvestris
1.13.11.5	partial purification	Ruta graveolens
1.13.11.5	partial purification	Melilotus albus
1.13.11.5	partial purification	Coleus scutellarioides
1.13.11.5	partial purification	Agrostemma githago
1.13.11.5	partial purification	Agave toumeyana
1.13.11.5	partial purification	Pimpinella anisum

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.13.11.5	additional information	-	-	Drosophyllum lusitanicum
1.13.11.5	0.125	-	-	Melilotus albus
1.13.11.5	0.17	-	-	Pimpinella anisum
1.13.11.5	0.25	-	-	Daucus carota
1.13.11.5	0.39	-	-	Ruta graveolens
1.13.11.5	0.405	-	-	Agrostemma githago
1.13.11.5	0.495	-	-	Glycine max
1.13.11.5	0.515	-	-	Phaseolus vulgaris
1.13.11.5	0.625	-	-	Agave toumeyana
1.13.11.5	1.16	-	-	Nicotiana sylvestris
1.13.11.5	2.59	-	-	Coleus scutellarioides

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1.13.11.5	homogentisate + O2	-	Phaseolus vulgaris	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Glycine max	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Daucus carota	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Nicotiana sylvestris	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Ruta graveolens	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Melilotus albus	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Coleus scutellarioides	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Agrostemma githago	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Agave toumeyana	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Drosophyllum lusitanicum	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	-	Pimpinella anisum	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Phaseolus vulgaris	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Glycine max	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Daucus carota	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Nicotiana sylvestris	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Ruta graveolens	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Melilotus albus	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Coleus scutellarioides	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Agrostemma githago	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Agave toumeyana	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Drosophyllum lusitanicum	4-maleylacetoacetate	-	?
1.13.11.5	homogentisate + O2	homogentisate ring-cleavage pathway, key enzyme of the ring-cleavage reaction in the catabolic sequence of enzymes from L-tyrosine to acetoacetate and fumarate	Pimpinella anisum	4-maleylacetoacetate	-	?