Any feedback?
Literature summary extracted from
- Homogentisate oxidase of liver (1955), J. Biol. Chem., 216, 479-487.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.5 | ascorbate | activates | Rattus norvegicus |  |
| 1.13.11.5 | cysteine | activates | Rattus norvegicus | |
| 1.13.11.5 | glutathione | activates | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.5 | 2,2'-dipyridyl | complete inhibition | Rattus norvegicus | |
| 1.13.11.5 | azide | - |
Rattus norvegicus | |
| 1.13.11.5 | benzoquinoneacetic acid | - |
Rattus norvegicus | |
| 1.13.11.5 | cyanide | - |
Rattus norvegicus | |
| 1.13.11.5 | cysteic acid | weak inhibition | Rattus norvegicus | |
| 1.13.11.5 | cysteine | inhibition not reversed by glutathione | Rattus norvegicus | |
| 1.13.11.5 | cystine | inhibition not reversed by glutathione | Rattus norvegicus | |
| 1.13.11.5 | diphosphate | - |
Rattus norvegicus | |
| 1.13.11.5 | Hg2+ | inhibition reversed by glutathione | Rattus norvegicus | |
| 1.13.11.5 | p-chloromercuribenzoate | inhibition reversed by glutathione | Rattus norvegicus | |
| 1.13.11.5 | phosphate | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.5 | Fe2+ | contains non-porphyrin iron, valence change of enzymic iron during reaction: ferric and ferrous iron | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.5 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.13.11.5 | partial purification | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.5 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.5 | homogentisate + O2 | - |
Rattus norvegicus | 4-maleylacetoacetate | product is 4-maleylacetoacetate, which is converted by a specific cis-trans isomerase to 4-fumarylacetoacetate | ? | |
| 1.13.11.5 | additional information | enzyme contains essential sulfhydryl groups | Rattus norvegicus | ? | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
