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Literature summary extracted from

  • Cesura, A.M.; Alberati-Giani, D.; Buchli, R.; Broger, C.; Kohler, C.; Vilbois, F.; Lahm, H.W.; Heitz, M.P.; Malherbe, P.
    Molecular characterization of kynurenine pathway enzymes: 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase (1996), Adv. Exp. Med. Biol., 398, 477-483.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.6 expression in human embryonic kidney HEK-293 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.6 4-Bromo-3-hydroxyanthranilic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.6 0.002
-
 3-hydroxyanthranilic acid
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.7 mitochondrial matrix
-
 Rattus norvegicus 5759
-
2.6.1.7 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.6 32590
-
 ion spray MS, recombinant enzyme Rattus norvegicus
1.13.11.6 32630
-
 ion spray MS Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.6 Rattus norvegicus
-
-
-
2.6.1.7 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2
-
 Rattus norvegicus 2-amino-3-carboxymuconate semialdehyde reacts spontaneously to quinolinic acid ?

Subunits

EC Number Subunits Comment Organism
1.13.11.6 monomer 1* 32589 or 32627, ion spray MS Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.6 additional information
-
 pI: 5.2 Rattus norvegicus