EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.6 | additional information | not at a concentration of 0.5 mM: L-tryptophan, quinolinic acid, kynurenic acid, nicotinic acid mononucleotide, picolinic acid, phthalic acid, glutaric acid, L-aspartic acid, L-glutamic acid, N-methyl-D-aspartic acid, kainic acid | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.6 | 0.003 | 0.0036 | 3-hydroxyanthranilic acid | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.13.11.6 | soluble | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.6 | Fe2+ | requirement | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.6 | 3-hydroxyanthranilate + O2 | Rattus norvegicus | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | 2-amino-3-carboxymuconate semialdehyde | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.6 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.6 | brain | regional distribution | Rattus norvegicus | - |
EC Number | Storage Stability | Organism |
---|---|---|
1.13.11.6 | -80°C, as homogenate stable for 2 months | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.6 | 3-hydroxyanthranilate + O2 | high selectivity for substrate | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | reacts spontaneously to quinolinic acid | ? | |
1.13.11.6 | 3-hydroxyanthranilate + O2 | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.13.11.6 | 30 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.13.11.6 | 6 | - |
- |
Rattus norvegicus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.13.11.6 | 4.5 | 7 | at pH 4.5: about 70% of activity maximum, at pH 7.0: about 50% of activity maximum | Rattus norvegicus |