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Literature summary extracted from
- Rat liver gamma-butyrobetaine hydroxylase catalyzed reaction: influence of potassium, substrates, and substrate analogues on hydroxylation and decarboxylation (1988), Biochemistry, 27, 2222-2228.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | catalase | - |
Rattus norvegicus | |
| 1.14.11.1 | Cs+ | increase of activity | Rattus norvegicus |  |
| 1.14.11.1 | GSH/GSH-peroxidase | increase of activity, more efficient in assay and during preincubation than catalase, protects the enzyme from increasing phosphate concentrations | Rattus norvegicus | |
| 1.14.11.1 | K+ | efficient coupling of decarboxylation and hydroxylation, stimulation | Rattus norvegicus | |
| 1.14.11.1 | NH4+ | increase of activity | Rattus norvegicus | |
| 1.14.11.1 | Rb+ | increase of activity | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | 3-Bromo-2-oxoglutarate | noncompetitive inhibition, 2-oxoglutarate as variable substrate | Rattus norvegicus | |
| 1.14.11.1 | 3-glutathione-2-oxoglutarate | noncompetitive to 2-oxoglutarate | Rattus norvegicus | |
| 1.14.11.1 | DL-carnitine | - |
Rattus norvegicus | |
| 1.14.11.1 | phosphate | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.1 | 0.029 | - |
gamma-butyrobetaine | - |
Rattus norvegicus | |
| 1.14.11.1 | 0.052 | - |
L-carnitine | - |
Rattus norvegicus | |
| 1.14.11.1 | 0.47 | - |
D-carnitine | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.11.1 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | Fe2+ | requirement | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.1 | 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
| 1.14.11.1 | D-carnitine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-carboxy-N,N,N-trimethyl-2-oxopropan-1-aminium + succinate + CO2 | - |
r | |
| 1.14.11.1 | L-carnitine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-carboxy-N,N,N-trimethyl-2-oxopropan-1-aminium + succinate + CO2 | - |
r | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.1 | 37 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.1 | ascorbate | - |
Rattus norvegicus | |
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