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Literature summary extracted from

  • Valtavaara, M.; Papponen, H.; Pirttilae, A.M.; Hiltunen, K.; Helander, H.; Myllylae, R.
    Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle (1997), J. Biol. Chem., 272, 6831-6834.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.4 expression in insect cells using a baculovirus vector Homo sapiens
1.14.11.4 expression in various human tissues Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.4 Fe2+ required, Km: 0.001-0.005 mM Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.4 88000
-
 2 * 88000 or 97000 SDS-PAGE, recombinant enzymes: isoform 2, possibly two forms are due to variation in the glycosylation of enzymes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.4 collagen + 2-oxoglutarate + O2 Homo sapiens enzyme required during collagen biosynthesis 5-hydroxylysyl-collagen + succinate + CO2
-
 ?
1.14.11.4 collagen + 2-oxoglutarate + O2 Homo sapiens influence the integrity and stability of collagen 5-hydroxylysyl-collagen + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.4 Homo sapiens O00469
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.11.4 glycoprotein
-
 Homo sapiens
1.14.11.4 side-chain modification hydroxylation of lysyl residue in -X-Lys-Gly Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.4 additional information existence of isoforms Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.4 collagen + 2-oxoglutarate + O2 enzyme required during collagen biosynthesis Homo sapiens 5-hydroxylysyl-collagen + succinate + CO2
-
 ?
1.14.11.4 collagen + 2-oxoglutarate + O2 influence the integrity and stability of collagen Homo sapiens 5-hydroxylysyl-collagen + succinate + CO2
-
 ?
1.14.11.4 peptidyl-L-lysine + 2-oxoglutarate + O2 synthetic peptides Homo sapiens peptidyl-5-hydroxy-L-lysine + succinate + CO2 hydroxy-L-lysine ?

Subunits

EC Number Subunits Comment Organism
1.14.11.4 homodimer 2 * 88000 or 97000 SDS-PAGE, recombinant enzymes: isoform 2, possibly two forms are due to variation in the glycosylation of enzymes Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.11.4 lysyl hydroxylase lysyl hydroxylase 1 and 2 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.4 ascorbate required Homo sapiens