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Literature summary extracted from

  • Kivirikko, K.I.; Myllylä, R.
    Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes (1982), Methods Enzymol., 82, 245-304.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.14.11.2 labile in tissue extracts Gallus gallus
1.14.11.2 labile in tissue extracts Homo sapiens
1.14.11.2 labile in tissue extracts Rattus norvegicus
1.14.11.2 stabilization by NaCl, detergents Gallus gallus
1.14.11.2 stabilization by NaCl, detergents Homo sapiens
1.14.11.2 stabilization by NaCl, detergents Rattus norvegicus
1.14.11.4 inactivation by freezing/thawing Gallus gallus
1.14.11.4 inactivation by freezing/thawing Homo sapiens
1.14.11.4 labile in tissue extracts Gallus gallus
1.14.11.4 labile in tissue extracts Homo sapiens
1.14.11.4 loss of activity during concentration Gallus gallus
1.14.11.4 loss of activity during concentration Homo sapiens
1.14.11.4 stabilization by detergents, NaCl Gallus gallus
1.14.11.4 stabilization by detergents, NaCl Homo sapiens
2.4.1.50 unstable during purification Gallus gallus
2.4.1.50 unstable in crude extracts Rattus norvegicus
2.4.1.66 concentrated enzyme, above 0.2 mg/ml, loses most of the activity Gallus gallus
2.4.1.66 stable in crude tissue extracts Gallus gallus
2.4.1.66 stable in crude tissue extracts Cavia porcellus
2.4.1.66 stable in crude tissue extracts Homo sapiens
2.4.1.66 stable in crude tissue extracts Rattus norvegicus
2.4.1.66 stable in crude tissue extracts Bos taurus
2.4.1.66 stable to repeated thawing and freezing, human liver or serum enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.50 concanavalin A
-
Gallus gallus
2.4.1.50 UDP
-
Gallus gallus
2.4.1.50 UDP
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.2 0.00000001
-
Protocollagen
-
Gallus gallus
1.14.11.2 0.00000001
-
Protocollagen
-
Homo sapiens
1.14.11.2 0.00000001
-
Protocollagen
-
Rattus norvegicus
1.14.11.2 0.01 0.03 (Pro-Pro-Gly)10
-
Homo sapiens
1.14.11.2 0.01 0.03 (L-Pro-L-Pro-Gly)10
-
Gallus gallus
1.14.11.2 0.01 0.03 (L-Pro-L-Pro-Gly)10
-
Rattus norvegicus
1.14.11.2 0.1 0.5 (L-Pro-L-Pro-Gly)5
-
Gallus gallus
1.14.11.2 0.1 0.5 (L-Pro-L-Pro-Gly)5
-
Homo sapiens
1.14.11.2 0.1 0.5 (L-Pro-L-Pro-Gly)5
-
Rattus norvegicus
1.14.11.4 0.4 0.5 Procollagen L-lysine
-
Gallus gallus
1.14.11.4 0.4 0.5 Procollagen L-lysine
-
Homo sapiens
2.4.1.50 additional information
-
additional information
-
Cavia porcellus
2.4.1.50 additional information
-
additional information Km: 15-35 mg/ml, gelatinized calf skin collagen Gallus gallus
2.4.1.50 additional information
-
additional information Km: 2-4 mg/ml, denatured citrate-soluble rat skin collagen Gallus gallus
2.4.1.50 0.1 0.2 hydroxylysyl acceptor sites
-
Gallus gallus
2.4.1.66 additional information
-
additional information
-
Homo sapiens
2.4.1.66 additional information
-
additional information Km: 0.5-1.0 mg/ml, denatured citrate soluble rat skin collagen Rattus norvegicus
2.4.1.66 additional information
-
additional information Km: 7-14 mg/ml, gelatinized calf skin collagen Gallus gallus
2.4.1.66 0.003 0.006 D-galactosylhydroxylysine galactosylhydroxylysyl acceptor sites Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.2 endoplasmic reticulum cisternae Gallus gallus 5783
-
1.14.11.2 endoplasmic reticulum cisternae Homo sapiens 5783
-
1.14.11.2 endoplasmic reticulum cisternae Rattus norvegicus 5783
-
1.14.11.4 endoplasmic reticulum
-
Gallus gallus 5783
-
1.14.11.4 endoplasmic reticulum
-
Homo sapiens 5783
-
2.4.1.50 endoplasmic reticulum
-
Gallus gallus 5783
-
2.4.1.50 endoplasmic reticulum
-
Cavia porcellus 5783
-
2.4.1.50 endoplasmic reticulum
-
Homo sapiens 5783
-
2.4.1.50 endoplasmic reticulum
-
Rattus norvegicus 5783
-
2.4.1.66 soluble
-
Gallus gallus
-
-
2.4.1.66 soluble
-
Cavia porcellus
-
-
2.4.1.66 soluble
-
Homo sapiens
-
-
2.4.1.66 soluble
-
Rattus norvegicus
-
-
2.4.1.66 soluble
-
Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+
-
Gallus gallus
1.14.11.2 Fe2+
-
Homo sapiens
1.14.11.2 Fe2+
-
Rattus norvegicus
1.14.11.4 Fe2+
-
Gallus gallus
1.14.11.4 Fe2+
-
Homo sapiens
2.4.1.50 Mn2+
-
Cavia porcellus
2.4.1.50 Mn2+
-
Rattus norvegicus
2.4.1.50 Mn2+ requirement Gallus gallus
2.4.1.50 Mn2+ requirement Homo sapiens
2.4.1.50 Mn2+ optimal concentration: 2 mM Gallus gallus
2.4.1.50 additional information
-
Cavia porcellus
2.4.1.50 additional information
-
Homo sapiens
2.4.1.50 additional information requires a bivalent cation Gallus gallus
2.4.1.66 Co2+
-
Gallus gallus
2.4.1.66 Co2+
-
Cavia porcellus
2.4.1.66 Co2+
-
Homo sapiens
2.4.1.66 Co2+
-
Rattus norvegicus
2.4.1.66 Co2+
-
Bos taurus
2.4.1.66 Fe2+
-
Cavia porcellus
2.4.1.66 Fe2+
-
Homo sapiens
2.4.1.66 Fe2+
-
Rattus norvegicus
2.4.1.66 Fe2+
-
Bos taurus
2.4.1.66 Fe2+ activation Gallus gallus
2.4.1.66 Fe2+ also in the presence of Mn2+, at low concentration Gallus gallus
2.4.1.66 Mn2+ requirement Gallus gallus
2.4.1.66 Mn2+ requirement Cavia porcellus
2.4.1.66 Mn2+ requirement Homo sapiens
2.4.1.66 Mn2+ requirement Rattus norvegicus
2.4.1.66 Mn2+ requirement Bos taurus
2.4.1.66 Mn2+ activates, 2 Mn2+-ions bound per enzyme molecule, mechanism Gallus gallus
2.4.1.66 Mn2+ activates, 2 Mn2+-ions bound per enzyme molecule, mechanism Cavia porcellus
2.4.1.66 Mn2+ activates, 2 Mn2+-ions bound per enzyme molecule, mechanism Homo sapiens
2.4.1.66 Mn2+ activates, 2 Mn2+-ions bound per enzyme molecule, mechanism Rattus norvegicus
2.4.1.66 Mn2+ activates, 2 Mn2+-ions bound per enzyme molecule, mechanism Bos taurus
2.4.1.66 Mn2+ 0.2-2.0 mM Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.2 230000 240000 gel filtration Homo sapiens
1.14.11.2 230000 240000 gel filtration Rattus norvegicus
1.14.11.2 230000 240000 sedimentation equilibrium centrifugation Gallus gallus
1.14.11.4 200000
-
-
Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine Gallus gallus involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine Cavia porcellus involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine Homo sapiens involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine Rattus norvegicus involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Gallus gallus involved in collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Cavia porcellus involved in collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Homo sapiens involved in collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Rattus norvegicus involved in collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Bos taurus involved in collagen biosynthesis UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Homo sapiens posttranslational modification of collagen UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Rattus norvegicus posttranslational modification of collagen UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen Homo sapiens together with EC 2.4.1.50 involved in biosynthesis of glucosylgalactosylhydroxylysine units in collagens, basement membranes and certain serum glycoproteins UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Gallus gallus
-
-
-
1.14.11.2 Homo sapiens
-
-
-
1.14.11.2 Rattus norvegicus
-
-
-
1.14.11.4 Gallus gallus
-
-
-
1.14.11.4 Homo sapiens
-
-
-
2.4.1.50 Cavia porcellus
-
-
-
2.4.1.50 Gallus gallus
-
-
-
2.4.1.50 Homo sapiens
-
-
-
2.4.1.50 Rattus norvegicus
-
-
-
2.4.1.66 Bos taurus
-
calf
-
2.4.1.66 Cavia porcellus
-
-
-
2.4.1.66 Gallus gallus
-
-
-
2.4.1.66 Homo sapiens
-
-
-
2.4.1.66 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.11.2 glycoprotein
-
Homo sapiens
1.14.11.2 glycoprotein subunit alpha: contains 16 residues of mannose, 1 residue of galactose and at least 2 residues of N-acetylglucosamine, subunit beta: contains 2 residues of mannose and 3 residues of galactose Gallus gallus
1.14.11.4 glycoprotein
-
Gallus gallus
1.14.11.4 glycoprotein
-
Homo sapiens
2.4.1.50 glycoprotein probably a glycoprotein Gallus gallus
2.4.1.66 glycoprotein
-
Gallus gallus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.2 of the beta-subunit using ammonium sulfate fractionation, chromatography on preimmune IgG column and immunoadsorbent column, and gel filtration Rattus norvegicus
1.14.11.2 using affinity chromatography on a column containing a polypeptide substrate of the enzyme linked to agarose, elution of the enzyme with a second peptide substrate and separation of the enzyme from this peptide by gel filtration Gallus gallus
1.14.11.2 using affinity chromatography on a column containing a polypeptide substrate of the enzyme linked to agarose, elution of the enzyme with a second peptide substrate and separation of the enzyme from this peptide by gel filtration Rattus norvegicus
1.14.11.2 using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration Gallus gallus
1.14.11.2 using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration Homo sapiens
1.14.11.2 using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration Rattus norvegicus
1.14.11.2 using fractionating precipitation, ion-exchange chromatography and gel filtration Gallus gallus
1.14.11.2 using fractionating precipitations, ion-exchange chromatographies and gel filtrations Rattus norvegicus
1.14.11.4
-
Gallus gallus
2.4.1.50 1000fold Gallus gallus
2.4.1.50 partial Gallus gallus
2.4.1.66
-
Homo sapiens
2.4.1.66 39800fold from embryo Gallus gallus
2.4.1.66 partial Rattus norvegicus
2.4.1.66 partial Bos taurus
2.4.1.66 skin, partial, solubilized with Triton X-100 Cavia porcellus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.66 UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine reaction mechanism Gallus gallus
2.4.1.66 UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine reaction mechanism Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 embryo
-
Gallus gallus
-
1.14.11.2 skin
-
Gallus gallus
-
1.14.11.2 skin
-
Homo sapiens
-
1.14.11.2 skin new born Rattus norvegicus
-
1.14.11.4 embryo
-
Gallus gallus
-
1.14.11.4 embryo
-
Homo sapiens
-
1.14.11.4 placenta
-
Homo sapiens
-
2.4.1.50 blood platelet
-
Homo sapiens
-
2.4.1.50 bone embryo bone Rattus norvegicus
-
2.4.1.50 embryo
-
Gallus gallus
-
2.4.1.50 embryo
-
Cavia porcellus
-
2.4.1.50 embryo
-
Homo sapiens
-
2.4.1.50 embryo embryo bone Rattus norvegicus
-
2.4.1.50 kidney
-
Rattus norvegicus
-
2.4.1.50 liver
-
Rattus norvegicus
-
2.4.1.50 skin
-
Cavia porcellus
-
2.4.1.50 skin cultured fibroblasts Homo sapiens
-
2.4.1.66 blood platelet
-
Homo sapiens
-
2.4.1.66 bone embryo bone Rattus norvegicus
-
2.4.1.66 cartilage embryonic Gallus gallus
-
2.4.1.66 cartilage embryonic Cavia porcellus
-
2.4.1.66 embryo
-
Gallus gallus
-
2.4.1.66 embryo
-
Cavia porcellus
-
2.4.1.66 embryo embryo bone Rattus norvegicus
-
2.4.1.66 fibroblast cultured skin fibroblasts Homo sapiens
-
2.4.1.66 kidney
-
Rattus norvegicus
-
2.4.1.66 liver
-
Gallus gallus
-
2.4.1.66 liver
-
Rattus norvegicus
-
2.4.1.66 macrophage peritoneal Rattus norvegicus
-
2.4.1.66 plasma
-
Homo sapiens
-
2.4.1.66 serum
-
Homo sapiens
-
2.4.1.66 skin
-
Cavia porcellus
-
2.4.1.66 skin cultured skin fibroblasts and skin extract Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.2 additional information
-
assay method Gallus gallus
1.14.11.2 additional information
-
assay method Homo sapiens
1.14.11.2 additional information
-
assay method Rattus norvegicus
1.14.11.2 additional information
-
specific activity of the purified beta-subunit Rattus norvegicus
1.14.11.2 1.3
-
purified enzyme Homo sapiens
1.14.11.2 1.3
-
purified enzyme Rattus norvegicus
1.14.11.2 1.5
-
purified enzyme Gallus gallus
1.14.11.4 additional information
-
assay methods Gallus gallus
1.14.11.4 additional information
-
assay methods Homo sapiens
2.4.1.50 0.0147
-
-
Gallus gallus
2.4.1.66 0.57
-
-
Gallus gallus

Storage Stability

EC Number Storage Stability Organism
1.14.11.4 -20°C Gallus gallus
1.14.11.4 -20°C Homo sapiens
2.4.1.66 -20°C, enzyme concentration 0.1 mg/ml, several months, 33% loss of activity Gallus gallus
2.4.1.66 4°C, enzyme concentration 0.1 mg/ml, 1 week, 33% loss of activity Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
Gallus gallus (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
r
1.14.11.2 (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
Rattus norvegicus (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
r
1.14.11.2 (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2
-
Gallus gallus (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2
-
r
1.14.11.2 (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2
-
Homo sapiens (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2
-
r
1.14.11.2 (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2
-
Rattus norvegicus (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2
-
r
1.14.11.2 (Pro-Pro-Gly)10 + 2-oxoglutarate + O2
-
Homo sapiens ? + succinate + CO2
-
?
1.14.11.2 (Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Gallus gallus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
1.14.11.2 (Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Homo sapiens (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
1.14.11.2 (Pro-Pro-Gly)n + 2-oxoglutarate + O2 n: 1,5,10 Rattus norvegicus (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 n: 1,5,10 ?
1.14.11.2 proline containing peptide + 2-oxoglutarate + O2
-
Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?
1.14.11.2 proline containing peptide + 2-oxoglutarate + O2
-
Homo sapiens 4-hydroxyproline containing peptide + succinate + CO2
-
?
1.14.11.2 proline containing peptide + 2-oxoglutarate + O2
-
Rattus norvegicus 4-hydroxyproline containing peptide + succinate + CO2
-
?
1.14.11.4 peptidyl-L-lysine + 2-oxoglutarate + O2 minimum sequence required: Xaa-Lys-Gly Gallus gallus peptidyl-5-hydroxy-L-lysine + succinate + CO2
-
?
1.14.11.4 peptidyl-L-lysine + 2-oxoglutarate + O2 minimum sequence required: Xaa-Lys-Gly Homo sapiens peptidyl-5-hydroxy-L-lysine + succinate + CO2
-
?
1.14.11.4 [procollagen] L-lysine + 2-oxoglutarate + O2
-
Gallus gallus [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
r
1.14.11.4 [procollagen] L-lysine + 2-oxoglutarate + O2
-
Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
r
2.4.1.50 additional information no acceptor: galactosylhydroxylysine Gallus gallus ?
-
?
2.4.1.50 additional information no acceptor: free hydroxylysine Gallus gallus ?
-
?
2.4.1.50 additional information no acceptor: free hydroxylysine Cavia porcellus ?
-
?
2.4.1.50 additional information no acceptor: free hydroxylysine Homo sapiens ?
-
?
2.4.1.50 additional information no acceptor: free hydroxylysine Rattus norvegicus ?
-
?
2.4.1.50 UDP-alpha-D-galactose + hydroxylysyl acceptor sites
-
Gallus gallus ?
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine
-
Homo sapiens UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine
-
Rattus norvegicus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine triple helix conformation of native collagen at 30°C prevents glycosylation Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine guinea pig skin collagen with sugar residues removed Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine guinea pig skin collagen with sugar residues removed Cavia porcellus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine bovine renal glomerular basement membrane Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine bovine anterior lens capsule collagen with carbohydrate units removed Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine gelatinized insoluble calf skin collagen Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine acceptor specificity: requires free epsilon-amino group in hydroxylysyl-residues Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine high specificity for galactosyl acceptor Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine high specificity for galactosyl acceptor Cavia porcellus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine denatured citrat-soluble rat skin collagen Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement Gallus gallus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement Cavia porcellus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement Homo sapiens UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.50 UDPgalactose + procollagen 5-hydroxy-L-lysine involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement Rattus norvegicus UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
?
2.4.1.66 additional information
-
Cavia porcellus ?
-
?
2.4.1.66 additional information
-
Homo sapiens ?
-
?
2.4.1.66 additional information no substrates: hydroxylysyl- or glucosylgalactosyl hydroxylysyl-residues Gallus gallus ?
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen highly specific Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen highly specific Cavia porcellus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen highly specific Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen highly specific Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen highly specific Bos taurus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen acceptor specificity Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen acceptor specificity Cavia porcellus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen acceptor specificity Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen acceptor specificity Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen acceptor specificity Bos taurus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen ordered binding of Mn2+, UDP-glucose and collagen at low Mn2+ concentration and of two Mn2+, UDP-glucose and collagen at high Mn2+ concentration Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen heat-denatured citrate-soluble rat skin collagen Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen heat-denatured citrate-soluble rat skin collagen Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen heat-denatured gelatinized calf skin collagen Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen heat-denatured gelatinized calf skin collagen Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen absolute requirement: free epsilon-amino group in hydroxylysyl-residues Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen absolute requirement: free epsilon-amino group in hydroxylysyl-residues Cavia porcellus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen absolute requirement: free epsilon-amino group in hydroxylysyl-residues Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen absolute requirement: free epsilon-amino group in hydroxylysyl-residues Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen absolute requirement: free epsilon-amino group in hydroxylysyl-residues Bos taurus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen involved in collagen biosynthesis Gallus gallus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen involved in collagen biosynthesis Cavia porcellus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen involved in collagen biosynthesis Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen involved in collagen biosynthesis Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen involved in collagen biosynthesis Bos taurus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen posttranslational modification of collagen Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen posttranslational modification of collagen Rattus norvegicus UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen together with EC 2.4.1.50 involved in biosynthesis of glucosylgalactosylhydroxylysine units in collagens, basement membranes and certain serum glycoproteins Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
?
2.4.1.66 UDP-glucose + D-galactosylhydroxylysine in vitro Gallus gallus UDP + 1,2-D-glucosyl-D-galactosylhydroxylysine
-
?
2.4.1.66 UDP-glucose + D-galactosylhydroxylysine in vitro Homo sapiens UDP + 1,2-D-glucosyl-D-galactosylhydroxylysine
-
?
2.4.1.66 UDP-glucose + D-galactosylsphingosine in vitro Gallus gallus UDP + 1,2-D-glucosyl-D-galactosylsphingosine
-
?
2.4.1.66 UDP-glucose + D-galactosylsphingosine good acceptor Gallus gallus UDP + 1,2-D-glucosyl-D-galactosylsphingosine
-
?

Subunits

EC Number Subunits Comment Organism
1.14.11.2 tetramer alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE Gallus gallus
1.14.11.2 tetramer alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE Homo sapiens
1.14.11.2 tetramer alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE Rattus norvegicus
1.14.11.4 dimer
-
Gallus gallus
2.4.1.66 monomer 1 * 72000-78000, value depends on the gel composition, SDS-PAGE Gallus gallus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.50 37
-
assay at Gallus gallus
2.4.1.50 37
-
assay at Cavia porcellus
2.4.1.50 37
-
assay at Homo sapiens
2.4.1.50 37
-
assay at Rattus norvegicus
2.4.1.66 37
-
assay at Gallus gallus
2.4.1.66 37
-
assay at Cavia porcellus
2.4.1.66 37
-
assay at Homo sapiens
2.4.1.66 37
-
assay at Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.11.4 additional information
-
additional information
-
Gallus gallus
1.14.11.4 additional information
-
additional information
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.2 7.4
-
-
Gallus gallus
1.14.11.2 7.4
-
-
Homo sapiens
1.14.11.2 7.4
-
-
Rattus norvegicus
1.14.11.4 7.4
-
-
Gallus gallus
1.14.11.4 7.4
-
-
Homo sapiens
2.4.1.50 7 7.4
-
Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.2 ascorbate
-
Gallus gallus
1.14.11.2 ascorbate
-
Homo sapiens
1.14.11.2 ascorbate
-
Rattus norvegicus
1.14.11.4 ascorbate
-
Gallus gallus
1.14.11.4 ascorbate
-
Homo sapiens