EC Number | General Stability | Organism |
---|---|---|
1.14.11.2 | labile in tissue extracts | Gallus gallus |
1.14.11.2 | labile in tissue extracts | Homo sapiens |
1.14.11.2 | labile in tissue extracts | Rattus norvegicus |
1.14.11.2 | stabilization by NaCl, detergents | Gallus gallus |
1.14.11.2 | stabilization by NaCl, detergents | Homo sapiens |
1.14.11.2 | stabilization by NaCl, detergents | Rattus norvegicus |
1.14.11.4 | inactivation by freezing/thawing | Gallus gallus |
1.14.11.4 | inactivation by freezing/thawing | Homo sapiens |
1.14.11.4 | labile in tissue extracts | Gallus gallus |
1.14.11.4 | labile in tissue extracts | Homo sapiens |
1.14.11.4 | loss of activity during concentration | Gallus gallus |
1.14.11.4 | loss of activity during concentration | Homo sapiens |
1.14.11.4 | stabilization by detergents, NaCl | Gallus gallus |
1.14.11.4 | stabilization by detergents, NaCl | Homo sapiens |
2.4.1.50 | unstable during purification | Gallus gallus |
2.4.1.50 | unstable in crude extracts | Rattus norvegicus |
2.4.1.66 | concentrated enzyme, above 0.2 mg/ml, loses most of the activity | Gallus gallus |
2.4.1.66 | stable in crude tissue extracts | Gallus gallus |
2.4.1.66 | stable in crude tissue extracts | Cavia porcellus |
2.4.1.66 | stable in crude tissue extracts | Homo sapiens |
2.4.1.66 | stable in crude tissue extracts | Rattus norvegicus |
2.4.1.66 | stable in crude tissue extracts | Bos taurus |
2.4.1.66 | stable to repeated thawing and freezing, human liver or serum enzyme | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.50 | concanavalin A | - |
Gallus gallus | |
2.4.1.50 | UDP | - |
Gallus gallus | |
2.4.1.50 | UDP | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.11.2 | 0.00000001 | - |
Protocollagen | - |
Gallus gallus | |
1.14.11.2 | 0.00000001 | - |
Protocollagen | - |
Homo sapiens | |
1.14.11.2 | 0.00000001 | - |
Protocollagen | - |
Rattus norvegicus | |
1.14.11.2 | 0.01 | 0.03 | (Pro-Pro-Gly)10 | - |
Homo sapiens | |
1.14.11.2 | 0.01 | 0.03 | (L-Pro-L-Pro-Gly)10 | - |
Gallus gallus | |
1.14.11.2 | 0.01 | 0.03 | (L-Pro-L-Pro-Gly)10 | - |
Rattus norvegicus | |
1.14.11.2 | 0.1 | 0.5 | (L-Pro-L-Pro-Gly)5 | - |
Gallus gallus | |
1.14.11.2 | 0.1 | 0.5 | (L-Pro-L-Pro-Gly)5 | - |
Homo sapiens | |
1.14.11.2 | 0.1 | 0.5 | (L-Pro-L-Pro-Gly)5 | - |
Rattus norvegicus | |
1.14.11.4 | 0.4 | 0.5 | Procollagen L-lysine | - |
Gallus gallus | |
1.14.11.4 | 0.4 | 0.5 | Procollagen L-lysine | - |
Homo sapiens | |
2.4.1.50 | additional information | - |
additional information | - |
Cavia porcellus | |
2.4.1.50 | additional information | - |
additional information | Km: 15-35 mg/ml, gelatinized calf skin collagen | Gallus gallus | |
2.4.1.50 | additional information | - |
additional information | Km: 2-4 mg/ml, denatured citrate-soluble rat skin collagen | Gallus gallus | |
2.4.1.50 | 0.1 | 0.2 | hydroxylysyl acceptor sites | - |
Gallus gallus | |
2.4.1.66 | additional information | - |
additional information | - |
Homo sapiens | |
2.4.1.66 | additional information | - |
additional information | Km: 0.5-1.0 mg/ml, denatured citrate soluble rat skin collagen | Rattus norvegicus | |
2.4.1.66 | additional information | - |
additional information | Km: 7-14 mg/ml, gelatinized calf skin collagen | Gallus gallus | |
2.4.1.66 | 0.003 | 0.006 | D-galactosylhydroxylysine | galactosylhydroxylysyl acceptor sites | Gallus gallus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.11.2 | endoplasmic reticulum | cisternae | Gallus gallus | 5783 | - |
1.14.11.2 | endoplasmic reticulum | cisternae | Homo sapiens | 5783 | - |
1.14.11.2 | endoplasmic reticulum | cisternae | Rattus norvegicus | 5783 | - |
1.14.11.4 | endoplasmic reticulum | - |
Gallus gallus | 5783 | - |
1.14.11.4 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
2.4.1.50 | endoplasmic reticulum | - |
Gallus gallus | 5783 | - |
2.4.1.50 | endoplasmic reticulum | - |
Cavia porcellus | 5783 | - |
2.4.1.50 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
2.4.1.50 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
2.4.1.66 | soluble | - |
Gallus gallus | - |
- |
2.4.1.66 | soluble | - |
Cavia porcellus | - |
- |
2.4.1.66 | soluble | - |
Homo sapiens | - |
- |
2.4.1.66 | soluble | - |
Rattus norvegicus | - |
- |
2.4.1.66 | soluble | - |
Bos taurus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.2 | Fe2+ | - |
Gallus gallus | |
1.14.11.2 | Fe2+ | - |
Homo sapiens | |
1.14.11.2 | Fe2+ | - |
Rattus norvegicus | |
1.14.11.4 | Fe2+ | - |
Gallus gallus | |
1.14.11.4 | Fe2+ | - |
Homo sapiens | |
2.4.1.50 | Mn2+ | - |
Cavia porcellus | |
2.4.1.50 | Mn2+ | - |
Rattus norvegicus | |
2.4.1.50 | Mn2+ | requirement | Gallus gallus | |
2.4.1.50 | Mn2+ | requirement | Homo sapiens | |
2.4.1.50 | Mn2+ | optimal concentration: 2 mM | Gallus gallus | |
2.4.1.50 | additional information | - |
Cavia porcellus | |
2.4.1.50 | additional information | - |
Homo sapiens | |
2.4.1.50 | additional information | requires a bivalent cation | Gallus gallus | |
2.4.1.66 | Co2+ | - |
Gallus gallus | |
2.4.1.66 | Co2+ | - |
Cavia porcellus | |
2.4.1.66 | Co2+ | - |
Homo sapiens | |
2.4.1.66 | Co2+ | - |
Rattus norvegicus | |
2.4.1.66 | Co2+ | - |
Bos taurus | |
2.4.1.66 | Fe2+ | - |
Cavia porcellus | |
2.4.1.66 | Fe2+ | - |
Homo sapiens | |
2.4.1.66 | Fe2+ | - |
Rattus norvegicus | |
2.4.1.66 | Fe2+ | - |
Bos taurus | |
2.4.1.66 | Fe2+ | activation | Gallus gallus | |
2.4.1.66 | Fe2+ | also in the presence of Mn2+, at low concentration | Gallus gallus | |
2.4.1.66 | Mn2+ | requirement | Gallus gallus | |
2.4.1.66 | Mn2+ | requirement | Cavia porcellus | |
2.4.1.66 | Mn2+ | requirement | Homo sapiens | |
2.4.1.66 | Mn2+ | requirement | Rattus norvegicus | |
2.4.1.66 | Mn2+ | requirement | Bos taurus | |
2.4.1.66 | Mn2+ | activates, 2 Mn2+-ions bound per enzyme molecule, mechanism | Gallus gallus | |
2.4.1.66 | Mn2+ | activates, 2 Mn2+-ions bound per enzyme molecule, mechanism | Cavia porcellus | |
2.4.1.66 | Mn2+ | activates, 2 Mn2+-ions bound per enzyme molecule, mechanism | Homo sapiens | |
2.4.1.66 | Mn2+ | activates, 2 Mn2+-ions bound per enzyme molecule, mechanism | Rattus norvegicus | |
2.4.1.66 | Mn2+ | activates, 2 Mn2+-ions bound per enzyme molecule, mechanism | Bos taurus | |
2.4.1.66 | Mn2+ | 0.2-2.0 mM | Gallus gallus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.11.2 | 230000 | 240000 | gel filtration | Homo sapiens |
1.14.11.2 | 230000 | 240000 | gel filtration | Rattus norvegicus |
1.14.11.2 | 230000 | 240000 | sedimentation equilibrium centrifugation | Gallus gallus |
1.14.11.4 | 200000 | - |
- |
Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | Gallus gallus | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | Cavia porcellus | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | Homo sapiens | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | Rattus norvegicus | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Gallus gallus | involved in collagen biosynthesis | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Cavia porcellus | involved in collagen biosynthesis | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Homo sapiens | involved in collagen biosynthesis | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Rattus norvegicus | involved in collagen biosynthesis | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Bos taurus | involved in collagen biosynthesis | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Homo sapiens | posttranslational modification of collagen | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Rattus norvegicus | posttranslational modification of collagen | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Homo sapiens | together with EC 2.4.1.50 involved in biosynthesis of glucosylgalactosylhydroxylysine units in collagens, basement membranes and certain serum glycoproteins | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.2 | Gallus gallus | - |
- |
- |
1.14.11.2 | Homo sapiens | - |
- |
- |
1.14.11.2 | Rattus norvegicus | - |
- |
- |
1.14.11.4 | Gallus gallus | - |
- |
- |
1.14.11.4 | Homo sapiens | - |
- |
- |
2.4.1.50 | Cavia porcellus | - |
- |
- |
2.4.1.50 | Gallus gallus | - |
- |
- |
2.4.1.50 | Homo sapiens | - |
- |
- |
2.4.1.50 | Rattus norvegicus | - |
- |
- |
2.4.1.66 | Bos taurus | - |
calf | - |
2.4.1.66 | Cavia porcellus | - |
- |
- |
2.4.1.66 | Gallus gallus | - |
- |
- |
2.4.1.66 | Homo sapiens | - |
- |
- |
2.4.1.66 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.14.11.2 | glycoprotein | - |
Homo sapiens |
1.14.11.2 | glycoprotein | subunit alpha: contains 16 residues of mannose, 1 residue of galactose and at least 2 residues of N-acetylglucosamine, subunit beta: contains 2 residues of mannose and 3 residues of galactose | Gallus gallus |
1.14.11.4 | glycoprotein | - |
Gallus gallus |
1.14.11.4 | glycoprotein | - |
Homo sapiens |
2.4.1.50 | glycoprotein | probably a glycoprotein | Gallus gallus |
2.4.1.66 | glycoprotein | - |
Gallus gallus |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.11.2 | of the beta-subunit using ammonium sulfate fractionation, chromatography on preimmune IgG column and immunoadsorbent column, and gel filtration | Rattus norvegicus |
1.14.11.2 | using affinity chromatography on a column containing a polypeptide substrate of the enzyme linked to agarose, elution of the enzyme with a second peptide substrate and separation of the enzyme from this peptide by gel filtration | Gallus gallus |
1.14.11.2 | using affinity chromatography on a column containing a polypeptide substrate of the enzyme linked to agarose, elution of the enzyme with a second peptide substrate and separation of the enzyme from this peptide by gel filtration | Rattus norvegicus |
1.14.11.2 | using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration | Gallus gallus |
1.14.11.2 | using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration | Homo sapiens |
1.14.11.2 | using affinity chromatography on a column containing poly-(L-proline) linked to agarose, elution with the same polypeptide of a lower molecular weight, and gel filtration | Rattus norvegicus |
1.14.11.2 | using fractionating precipitation, ion-exchange chromatography and gel filtration | Gallus gallus |
1.14.11.2 | using fractionating precipitations, ion-exchange chromatographies and gel filtrations | Rattus norvegicus |
1.14.11.4 | - |
Gallus gallus |
2.4.1.50 | 1000fold | Gallus gallus |
2.4.1.50 | partial | Gallus gallus |
2.4.1.66 | - |
Homo sapiens |
2.4.1.66 | 39800fold from embryo | Gallus gallus |
2.4.1.66 | partial | Rattus norvegicus |
2.4.1.66 | partial | Bos taurus |
2.4.1.66 | skin, partial, solubilized with Triton X-100 | Cavia porcellus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.4.1.66 | UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine | reaction mechanism | Gallus gallus | |
2.4.1.66 | UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine | reaction mechanism | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.2 | embryo | - |
Gallus gallus | - |
1.14.11.2 | skin | - |
Gallus gallus | - |
1.14.11.2 | skin | - |
Homo sapiens | - |
1.14.11.2 | skin | new born | Rattus norvegicus | - |
1.14.11.4 | embryo | - |
Gallus gallus | - |
1.14.11.4 | embryo | - |
Homo sapiens | - |
1.14.11.4 | placenta | - |
Homo sapiens | - |
2.4.1.50 | blood platelet | - |
Homo sapiens | - |
2.4.1.50 | bone | embryo bone | Rattus norvegicus | - |
2.4.1.50 | embryo | - |
Gallus gallus | - |
2.4.1.50 | embryo | - |
Cavia porcellus | - |
2.4.1.50 | embryo | - |
Homo sapiens | - |
2.4.1.50 | embryo | embryo bone | Rattus norvegicus | - |
2.4.1.50 | kidney | - |
Rattus norvegicus | - |
2.4.1.50 | liver | - |
Rattus norvegicus | - |
2.4.1.50 | skin | - |
Cavia porcellus | - |
2.4.1.50 | skin | cultured fibroblasts | Homo sapiens | - |
2.4.1.66 | blood platelet | - |
Homo sapiens | - |
2.4.1.66 | bone | embryo bone | Rattus norvegicus | - |
2.4.1.66 | cartilage | embryonic | Gallus gallus | - |
2.4.1.66 | cartilage | embryonic | Cavia porcellus | - |
2.4.1.66 | embryo | - |
Gallus gallus | - |
2.4.1.66 | embryo | - |
Cavia porcellus | - |
2.4.1.66 | embryo | embryo bone | Rattus norvegicus | - |
2.4.1.66 | fibroblast | cultured skin fibroblasts | Homo sapiens | - |
2.4.1.66 | kidney | - |
Rattus norvegicus | - |
2.4.1.66 | liver | - |
Gallus gallus | - |
2.4.1.66 | liver | - |
Rattus norvegicus | - |
2.4.1.66 | macrophage | peritoneal | Rattus norvegicus | - |
2.4.1.66 | plasma | - |
Homo sapiens | - |
2.4.1.66 | serum | - |
Homo sapiens | - |
2.4.1.66 | skin | - |
Cavia porcellus | - |
2.4.1.66 | skin | cultured skin fibroblasts and skin extract | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.11.2 | additional information | - |
assay method | Gallus gallus |
1.14.11.2 | additional information | - |
assay method | Homo sapiens |
1.14.11.2 | additional information | - |
assay method | Rattus norvegicus |
1.14.11.2 | additional information | - |
specific activity of the purified beta-subunit | Rattus norvegicus |
1.14.11.2 | 1.3 | - |
purified enzyme | Homo sapiens |
1.14.11.2 | 1.3 | - |
purified enzyme | Rattus norvegicus |
1.14.11.2 | 1.5 | - |
purified enzyme | Gallus gallus |
1.14.11.4 | additional information | - |
assay methods | Gallus gallus |
1.14.11.4 | additional information | - |
assay methods | Homo sapiens |
2.4.1.50 | 0.0147 | - |
- |
Gallus gallus |
2.4.1.66 | 0.57 | - |
- |
Gallus gallus |
EC Number | Storage Stability | Organism |
---|---|---|
1.14.11.4 | -20°C | Gallus gallus |
1.14.11.4 | -20°C | Homo sapiens |
2.4.1.66 | -20°C, enzyme concentration 0.1 mg/ml, several months, 33% loss of activity | Gallus gallus |
2.4.1.66 | 4°C, enzyme concentration 0.1 mg/ml, 1 week, 33% loss of activity | Gallus gallus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.2 | (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Gallus gallus | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
1.14.11.2 | (L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
1.14.11.2 | (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2 | - |
Gallus gallus | (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
1.14.11.2 | (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2 | - |
Homo sapiens | (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
1.14.11.2 | (L-Pro-L-Pro-Gly)5 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | (L-Pro-L-Pro-Gly)5-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r | |
1.14.11.2 | (Pro-Pro-Gly)10 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? + succinate + CO2 | - |
? | |
1.14.11.2 | (Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Gallus gallus | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? | |
1.14.11.2 | (Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Homo sapiens | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? | |
1.14.11.2 | (Pro-Pro-Gly)n + 2-oxoglutarate + O2 | n: 1,5,10 | Rattus norvegicus | (Pro-4-hydroxy-Pro-Gly)n + succinate + CO2 | n: 1,5,10 | ? | |
1.14.11.2 | proline containing peptide + 2-oxoglutarate + O2 | - |
Gallus gallus | 4-hydroxyproline containing peptide + succinate + CO2 | - |
? | |
1.14.11.2 | proline containing peptide + 2-oxoglutarate + O2 | - |
Homo sapiens | 4-hydroxyproline containing peptide + succinate + CO2 | - |
? | |
1.14.11.2 | proline containing peptide + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 4-hydroxyproline containing peptide + succinate + CO2 | - |
? | |
1.14.11.4 | peptidyl-L-lysine + 2-oxoglutarate + O2 | minimum sequence required: Xaa-Lys-Gly | Gallus gallus | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
1.14.11.4 | peptidyl-L-lysine + 2-oxoglutarate + O2 | minimum sequence required: Xaa-Lys-Gly | Homo sapiens | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
1.14.11.4 | [procollagen] L-lysine + 2-oxoglutarate + O2 | - |
Gallus gallus | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
r | |
1.14.11.4 | [procollagen] L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
r | |
2.4.1.50 | additional information | no acceptor: galactosylhydroxylysine | Gallus gallus | ? | - |
? | |
2.4.1.50 | additional information | no acceptor: free hydroxylysine | Gallus gallus | ? | - |
? | |
2.4.1.50 | additional information | no acceptor: free hydroxylysine | Cavia porcellus | ? | - |
? | |
2.4.1.50 | additional information | no acceptor: free hydroxylysine | Homo sapiens | ? | - |
? | |
2.4.1.50 | additional information | no acceptor: free hydroxylysine | Rattus norvegicus | ? | - |
? | |
2.4.1.50 | UDP-alpha-D-galactose + hydroxylysyl acceptor sites | - |
Gallus gallus | ? | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | - |
Homo sapiens | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | - |
Rattus norvegicus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | triple helix conformation of native collagen at 30°C prevents glycosylation | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | guinea pig skin collagen with sugar residues removed | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | guinea pig skin collagen with sugar residues removed | Cavia porcellus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | bovine renal glomerular basement membrane | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | bovine anterior lens capsule collagen with carbohydrate units removed | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | gelatinized insoluble calf skin collagen | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | acceptor specificity: requires free epsilon-amino group in hydroxylysyl-residues | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | high specificity for galactosyl acceptor | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | high specificity for galactosyl acceptor | Cavia porcellus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | denatured citrat-soluble rat skin collagen | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | Gallus gallus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | Cavia porcellus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | Homo sapiens | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.50 | UDPgalactose + procollagen 5-hydroxy-L-lysine | involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement | Rattus norvegicus | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? | |
2.4.1.66 | additional information | - |
Cavia porcellus | ? | - |
? | |
2.4.1.66 | additional information | - |
Homo sapiens | ? | - |
? | |
2.4.1.66 | additional information | no substrates: hydroxylysyl- or glucosylgalactosyl hydroxylysyl-residues | Gallus gallus | ? | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | highly specific | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | highly specific | Cavia porcellus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | highly specific | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | highly specific | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | highly specific | Bos taurus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | acceptor specificity | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | acceptor specificity | Cavia porcellus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | acceptor specificity | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | acceptor specificity | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | acceptor specificity | Bos taurus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | ordered binding of Mn2+, UDP-glucose and collagen at low Mn2+ concentration and of two Mn2+, UDP-glucose and collagen at high Mn2+ concentration | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | heat-denatured citrate-soluble rat skin collagen | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | heat-denatured citrate-soluble rat skin collagen | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | heat-denatured gelatinized calf skin collagen | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | heat-denatured gelatinized calf skin collagen | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | absolute requirement: free epsilon-amino group in hydroxylysyl-residues | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | absolute requirement: free epsilon-amino group in hydroxylysyl-residues | Cavia porcellus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | absolute requirement: free epsilon-amino group in hydroxylysyl-residues | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | absolute requirement: free epsilon-amino group in hydroxylysyl-residues | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | absolute requirement: free epsilon-amino group in hydroxylysyl-residues | Bos taurus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | involved in collagen biosynthesis | Gallus gallus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | involved in collagen biosynthesis | Cavia porcellus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | involved in collagen biosynthesis | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | involved in collagen biosynthesis | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | involved in collagen biosynthesis | Bos taurus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | posttranslational modification of collagen | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | posttranslational modification of collagen | Rattus norvegicus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | together with EC 2.4.1.50 involved in biosynthesis of glucosylgalactosylhydroxylysine units in collagens, basement membranes and certain serum glycoproteins | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + D-galactosylhydroxylysine | in vitro | Gallus gallus | UDP + 1,2-D-glucosyl-D-galactosylhydroxylysine | - |
? | |
2.4.1.66 | UDP-glucose + D-galactosylhydroxylysine | in vitro | Homo sapiens | UDP + 1,2-D-glucosyl-D-galactosylhydroxylysine | - |
? | |
2.4.1.66 | UDP-glucose + D-galactosylsphingosine | in vitro | Gallus gallus | UDP + 1,2-D-glucosyl-D-galactosylsphingosine | - |
? | |
2.4.1.66 | UDP-glucose + D-galactosylsphingosine | good acceptor | Gallus gallus | UDP + 1,2-D-glucosyl-D-galactosylsphingosine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.11.2 | tetramer | alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE | Gallus gallus |
1.14.11.2 | tetramer | alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE | Homo sapiens |
1.14.11.2 | tetramer | alpha2 beta2, alpha: 64000, beta: 60000, ratio 1 to 1, SDS-PAGE | Rattus norvegicus |
1.14.11.4 | dimer | - |
Gallus gallus |
2.4.1.66 | monomer | 1 * 72000-78000, value depends on the gel composition, SDS-PAGE | Gallus gallus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.50 | 37 | - |
assay at | Gallus gallus |
2.4.1.50 | 37 | - |
assay at | Cavia porcellus |
2.4.1.50 | 37 | - |
assay at | Homo sapiens |
2.4.1.50 | 37 | - |
assay at | Rattus norvegicus |
2.4.1.66 | 37 | - |
assay at | Gallus gallus |
2.4.1.66 | 37 | - |
assay at | Cavia porcellus |
2.4.1.66 | 37 | - |
assay at | Homo sapiens |
2.4.1.66 | 37 | - |
assay at | Bos taurus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.11.4 | additional information | - |
additional information | - |
Gallus gallus | |
1.14.11.4 | additional information | - |
additional information | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.11.2 | 7.4 | - |
- |
Gallus gallus |
1.14.11.2 | 7.4 | - |
- |
Homo sapiens |
1.14.11.2 | 7.4 | - |
- |
Rattus norvegicus |
1.14.11.4 | 7.4 | - |
- |
Gallus gallus |
1.14.11.4 | 7.4 | - |
- |
Homo sapiens |
2.4.1.50 | 7 | 7.4 | - |
Gallus gallus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.2 | ascorbate | - |
Gallus gallus | |
1.14.11.2 | ascorbate | - |
Homo sapiens | |
1.14.11.2 | ascorbate | - |
Rattus norvegicus | |
1.14.11.4 | ascorbate | - |
Gallus gallus | |
1.14.11.4 | ascorbate | - |
Homo sapiens |