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Literature summary extracted from
- Studies on aldosterone biosynthesis in vitro (1966), Biochemistry, 5, 1795-1804.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.14.15.5 | lyophilization, mitochondria lose 90% activity | Cavia porcellus |
| 1.14.15.5 | lyophilization, mitochondria lose 90% activity | Bos taurus |
| 1.14.15.5 | lyophilization, mitochondria lose 90% activity | Ovis aries |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.5 | 1,2-Bis(3-pyridyl)-2-methyl-1-propanone | SU 4885 | Bos taurus |  |
| 1.14.15.5 | 1,2-Bis(3-pyridyl)-2-methyl-1-propanone | SU 4885 | Cavia porcellus | |
| 1.14.15.5 | 1,2-Bis(3-pyridyl)-2-methyl-1-propanone | SU 4885 | Ovis aries | |
| 1.14.15.5 | 18-hydroxycorticosterone | product inhibition | Bos taurus | |
| 1.14.15.5 | 18-hydroxycorticosterone | product inhibition | Cavia porcellus | |
| 1.14.15.5 | 18-hydroxycorticosterone | product inhibition | Ovis aries | |
| 1.14.15.5 | 3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine | SU 9055 | Bos taurus | |
| 1.14.15.5 | 3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine | SU 9055 | Cavia porcellus | |
| 1.14.15.5 | 3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine | SU 9055 | Ovis aries | |
| 1.14.15.5 | Co2+ | - |
Bos taurus | |
| 1.14.15.5 | Co2+ | - |
Cavia porcellus | |
| 1.14.15.5 | Co2+ | - |
Ovis aries | |
| 1.14.15.5 | Cu2+ | - |
Bos taurus | |
| 1.14.15.5 | Cu2+ | - |
Cavia porcellus | |
| 1.14.15.5 | Cu2+ | - |
Ovis aries | |
| 1.14.15.5 | diethyldithiocarbamate | - |
Bos taurus | |
| 1.14.15.5 | diethyldithiocarbamate | - |
Cavia porcellus | |
| 1.14.15.5 | diethyldithiocarbamate | - |
Ovis aries | |
| 1.14.15.5 | Fe3+ | - |
Bos taurus | |
| 1.14.15.5 | Fe3+ | - |
Cavia porcellus | |
| 1.14.15.5 | Fe3+ | - |
Ovis aries | |
| 1.14.15.5 | Formamidine acetate | - |
Bos taurus | |
| 1.14.15.5 | Formamidine acetate | - |
Cavia porcellus | |
| 1.14.15.5 | Formamidine acetate | - |
Ovis aries | |
| 1.14.15.5 | Hg2+ | - |
Bos taurus | |
| 1.14.15.5 | Hg2+ | - |
Cavia porcellus | |
| 1.14.15.5 | Hg2+ | - |
Ovis aries | |
| 1.14.15.5 | Mn2+ | - |
Bos taurus | |
| 1.14.15.5 | Mn2+ | - |
Cavia porcellus | |
| 1.14.15.5 | Mn2+ | - |
Ovis aries | |
| 1.14.15.5 | NEM | higher concentrations | Bos taurus | |
| 1.14.15.5 | NEM | higher concentrations | Cavia porcellus | |
| 1.14.15.5 | NEM | higher concentrations | Ovis aries | |
| 1.14.15.5 | p-chloromercuribenzoate | - |
Bos taurus | |
| 1.14.15.5 | p-chloromercuribenzoate | - |
Cavia porcellus | |
| 1.14.15.5 | p-chloromercuribenzoate | - |
Ovis aries | |
| 1.14.15.5 | SU 10603 | less effective | Bos taurus | |
| 1.14.15.5 | SU 10603 | less effective | Cavia porcellus | |
| 1.14.15.5 | SU 10603 | less effective | Ovis aries | |
| 1.14.15.5 | Zn2+ | - |
Bos taurus | |
| 1.14.15.5 | Zn2+ | - |
Cavia porcellus | |
| 1.14.15.5 | Zn2+ | - |
Ovis aries | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.15.5 | mitochondrial crista | - |
Cavia porcellus | 30061 | - |
| 1.14.15.5 | mitochondrial crista | - |
Bos taurus | 30061 | - |
| 1.14.15.5 | mitochondrial crista | - |
Ovis aries | 30061 | - |
| 1.14.15.5 | mitochondrial membrane | - |
Cavia porcellus | 31966 | - |
| 1.14.15.5 | mitochondrial membrane | - |
Bos taurus | 31966 | - |
| 1.14.15.5 | mitochondrial membrane | - |
Ovis aries | 31966 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.5 | Ca2+ | increase of activity, Na+, K+ alone or together are ineffective | Cavia porcellus | |
| 1.14.15.5 | Ca2+ | increase of activity, Na+, K+ alone or together are ineffective | Bos taurus | |
| 1.14.15.5 | Ca2+ | increase of activity, Na+, K+ alone or together are ineffective | Ovis aries | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | Cavia porcellus | reaction in the biosynthesis of aldosterone | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | Bos taurus | reaction in the biosynthesis of aldosterone | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | Ovis aries | reaction in the biosynthesis of aldosterone | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.5 | Bos taurus | - |
- |
- |
| 1.14.15.5 | Cavia porcellus | - |
- |
- |
| 1.14.15.5 | Ovis aries | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.15.5 | adrenal cortex | - |
Cavia porcellus | - |
| 1.14.15.5 | adrenal cortex | - |
Bos taurus | - |
| 1.14.15.5 | adrenal cortex | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | - |
Cavia porcellus | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | - |
Bos taurus | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | - |
Ovis aries | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | reaction in the biosynthesis of aldosterone | Cavia porcellus | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | reaction in the biosynthesis of aldosterone | Bos taurus | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
| 1.14.15.5 | corticosterone + reduced adrenal ferredoxin + O2 | reaction in the biosynthesis of aldosterone | Ovis aries | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.15.5 | 37 | - |
assay at | Cavia porcellus |
| 1.14.15.5 | 37 | - |
assay at | Bos taurus |
| 1.14.15.5 | 37 | - |
assay at | Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.15.5 | 7.3 | - |
assay at | Cavia porcellus |
| 1.14.15.5 | 7.3 | - |
assay at | Bos taurus |
| 1.14.15.5 | 7.3 | - |
assay at | Ovis aries |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.5 | NADPH | activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH | Cavia porcellus | |
| 1.14.15.5 | NADPH | activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH | Bos taurus | |
| 1.14.15.5 | NADPH | activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH | Ovis aries | |
| 1.14.15.5 | reduced adrenal ferredoxin | - |
Cavia porcellus | |
| 1.14.15.5 | reduced adrenal ferredoxin | - |
Bos taurus | |
| 1.14.15.5 | reduced adrenal ferredoxin | - |
Ovis aries | |
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