Any feedback?
Literature summary extracted from
- Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism (1998), Med. Res. Rev., 18, 43-89.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.5 | (NH4)2Mo7O24 | - |
Rattus norvegicus |  |
| 1.14.16.5 | 1,10-phenanthroline | - |
Rattus norvegicus | |
| 1.14.16.5 | 8-hydroxyquinoline | - |
Rattus norvegicus | |
| 1.14.16.5 | CsCl | - |
Rattus norvegicus | |
| 1.14.16.5 | Digitonin | - |
Rattus norvegicus | |
| 1.14.16.5 | EDTA | 5.0 mM, 16% inhibition | Rattus norvegicus | |
| 1.14.16.5 | hexadecyl-L-alpha-lyso-phosphatidylcholine | competitive | Rattus norvegicus | |
| 1.14.16.5 | hexadecylphosphocholine | - |
Rattus norvegicus | |
| 1.14.16.5 | KCl | - |
Rattus norvegicus | |
| 1.14.16.5 | KCN | - |
Rattus norvegicus | |
| 1.14.16.5 | Mega-10 | above 5.7 mM; noncompetitive | Rattus norvegicus | |
| 1.14.16.5 | Na2SO4 | - |
Rattus norvegicus | |
| 1.14.16.5 | NaCl | - |
Rattus norvegicus | |
| 1.14.16.5 | NaN3 | - |
Rattus norvegicus | |
| 1.14.16.5 | NEM | 8.0 mM | Rattus norvegicus | |
| 1.14.16.5 | octadecan-1-ol | competitive | Rattus norvegicus | |
| 1.14.16.5 | PCMB | - |
Rattus norvegicus | |
| 1.14.16.5 | tetradecanoyl-L-alpha-lyso-phosphatidylcholine | competitive | Rattus norvegicus | |
| 1.14.16.5 | tetradecylphosphocholine | competitive | Rattus norvegicus | |
| 1.14.16.5 | ZnCl2 | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.16.5 | additional information | - |
additional information | influence of detergents in Km-value for batyl alcohol | Rattus norvegicus | |
| 1.14.16.5 | 0.012 | - |
RS-3-hexadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0183 | - |
2-hexadecyloxypropane-1,3-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0204 | - |
S-3-octadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0247 | - |
RS-3-octadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0313 | - |
2-octadecyloxyethan-1-ol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0329 | - |
R-3-hexadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0375 | - |
S-3-hexadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0397 | - |
R-3-pentadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0397 | - |
cis-RS-3-octadec-9'-enyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0415 | - |
R-3-octadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0427 | - |
R-3-tridecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0474 | - |
R-3-dodecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.0718 | - |
R-3-heptadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.072 | - |
RS-3-octadecyloxypropane-1,2-diol | with 6,7-dimethyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.121 | - |
RS-hexadecylthiopropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.228 | - |
2-hexadecylthioethan-1-ol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.265 | - |
3-hexadecyloxy-1-methoxypropan-1-ol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.428 | - |
RS-octadecylthiopropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.521 | - |
2-octadecylthioethan-1-ol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.66 | - |
RS-3-hexadecyloxypropane-1,2-diol | with 6,7-dimethyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 0.937 | - |
R-3-nonadecyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
| 1.14.16.5 | 51.3 | - |
RS-3-heptyloxypropane-1,2-diol | with 6-methyl-5,6,7,8-tetrahydropterin as cofactor | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.16.5 | membrane | bound to | Rattus norvegicus | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.5 | Canis lupus familiaris | - |
- |
- |
| 1.14.16.5 | Cavia porcellus | - |
- |
- |
| 1.14.16.5 | Meriones sp. | - |
gerbil | - |
| 1.14.16.5 | Mesocricetus auratus | - |
- |
- |
| 1.14.16.5 | Mus musculus | - |
- |
- |
| 1.14.16.5 | Oryctolagus cuniculus | - |
- |
- |
| 1.14.16.5 | Rattus norvegicus | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.14.16.5 | 1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | mechanism | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.5 | liver | - |
Cavia porcellus | - |
| 1.14.16.5 | liver | - |
Mus musculus | - |
| 1.14.16.5 | liver | - |
Rattus norvegicus | - |
| 1.14.16.5 | liver | - |
Oryctolagus cuniculus | - |
| 1.14.16.5 | liver | - |
Canis lupus familiaris | - |
| 1.14.16.5 | liver | - |
Mesocricetus auratus | - |
| 1.14.16.5 | liver | - |
Meriones sp. | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.16.5 | -20°C or -70°C, stable for many months | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.5 | (RS)-batyl alcohol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 1-O-hexadecyl-sn-glycero-3-phosphocholine + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxy-ethan-1-ol + 5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxy-ethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxyethan-1-ol + 5,6,7,8-tetrahydrofolic acid + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxyethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxyethan-1-ol + 6R-tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecyloxypropane-1,3-diol + 6-methyl-5,6,7,8-tetrahydropterin | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-hexadecylthioethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-octadecyloxyethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 2-octadecylthioethan-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 3-hexadecyloxy-1-methoxypropan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 3-hexadecyloxy-2-methoxypropan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | 3-O-hexadecyl glycerol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | batyl alcohol + 6R-tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | cis-RS-3-octadec-9'-enyloxypropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | hexadecyl glycerol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Cavia porcellus | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Mus musculus | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Oryctolagus cuniculus | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Canis lupus familiaris | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Mesocricetus auratus | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | hexadecylglycerol + tetrahydrobiopterin + O2 | - |
Meriones sp. | hexadecanal + glycerol + dihydrobiopterin + H2O | - |
? | |
| 1.14.16.5 | R-3-dodecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-eicosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-heneicosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-heptadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-hexadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-nonadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-nonadecyloxypropane-1,2-diol + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
r | |
| 1.14.16.5 | R-3-octadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-pentadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-tridecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | R-3-undecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-docosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-dodecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-heptyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-hexyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-nonyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-octyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-pentyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-propyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-3-tetradecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-cyclohexylmethoxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-hexadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | RS-octadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.5 | S-3-hexadecyloxypropane-1,2-diol + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | ? | - |
r | |
| 1.14.16.5 | S-3-octadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.5 | (6R)-tetrahydrobiopterin | - |
Rattus norvegicus | |
| 1.14.16.5 | (RS)-6,7-dimethyl-5,6,7,8-tetrahydropterin | - |
Rattus norvegicus | |
| 1.14.16.5 | (RS)-6-methyl-5,6,7,8-tetrahydropterin | - |
Rattus norvegicus | |
| 1.14.16.5 | 5,6,7,8-tetrahydrofolic acid | - |
Rattus norvegicus | |
| 1.14.16.5 | 5,6,7,8-Tetrahydropterin | - |
Rattus norvegicus | |
| 1.14.16.5 | tetrahydrobiopterin | - |
Rattus norvegicus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.16.5 | 0.32 | - |
tetradecyl phosphocholine | - |
Rattus norvegicus | |
| 1.14.16.5 | 0.33 | - |
tetradecanoyl-L-alpha-lyso-phosphatidylcholine | - |
Rattus norvegicus | |
| 1.14.16.5 | 0.37 | - |
hexadecylphosphocholine | - |
Rattus norvegicus | |
| 1.14.16.5 | 0.77 | - |
octadecan-1-ol | - |
Rattus norvegicus | |
| 1.14.16.5 | 1.74 | - |
Mega-10 | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
