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Literature summary extracted from

  • Narita, M.; Ishida, T.; Tomoyoshi, T.; Nozaki, M.; Horiike, K.
    A natural variant of bovine dopamine beta-monooxygenase with phenylalanine as residue 208: purification and characterization of the variant homo- and heterotetramers of (F208)4 and (F208)2(L208)2 (1996), FEBS Lett., 396, 208-212.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.17.1 L208F a natural variant - three phenotypes of enzyme isolated: 4 * L208-homoenzyme, 4 * F208-homoenzyme and 2 * F208, 2 * L208-heteroenzyme, no significant difference in kinetic properties Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.17.1 65000
-
 4 * 65000, deduced from cDNA Bos taurus
1.14.17.1 220000 250000 220000 Da, L208 homoenzyme, 230000 Da, F208 homoenzyme, 250000 Da, F208/L208 heteroenzyme, low-angle laser light scattering-photometry Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.1
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.1 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.1 tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.17.1 tetramer 4 * 65000, deduced from cDNA Bos taurus