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Literature summary extracted from

  • Wimalasena, K.; Dharmasena, S.; Wimalasena, D.S.; Hughbanks-Wheaton, D.K.
    Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation (1996), J. Biol. Chem., 271, 26032-26043.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.17.1 fumarate
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 additional information ascorbic acid derivates inhibit the enzyme at higher concentrations Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 additional information
-
 additional information Km of N,N-dimethyl-1,4-phenylenediamine and ascorbic acid derivatives Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.1 chromaffin granule
-
 Bos taurus 42583
-
1.14.17.1 membrane
-
 Bos taurus 16020
-
1.14.17.1 soluble
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.17.1 dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 N,N-dimethyl-1,4-phenylenediamine and ascorbic acid derivates are efficient reductants for the enzyme Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?