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Literature summary extracted from

  • Bossard, M.J.; Klinman, J.P.
    Mechanism-based inhibition of dopamine beta-monooxygenase by aldehydes and amides (1986), J. Biol. Chem., 261, 16421-16427.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 2-hydroxyphenylacetaldehyde
-
 Bos taurus
1.14.17.1 p-Hydroxyphenylacetamide
-
 Bos taurus
1.14.17.1 phenylacetaldehyde
-
 Bos taurus
1.14.17.1 phenylacetamide
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 7.4
-
 phenylacetaldehyde
-
 Bos taurus
1.14.17.1 7.9
-
 phenylacetaldehyde
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.1 chromaffin granule
-
 Bos taurus 42583
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.17.1 dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 phenylacetaldehyde + ascorbate + O2
-
 Bos taurus ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.17.1 1.7
-
 phenylacetaldehyde
-
 Bos taurus