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Literature summary extracted from

  • Kruse, L.I.; DeWolf, W.E.; Chambers, P.A.; Goodhart, P.J.
    Design and kinetic characterization of multisubstrate inhibitors of dopamine beta-hydroxylase (1986), Biochemistry, 25, 7271-7278.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 1-(4-Hydroxybenzyl)imidazole-2-thiol
-
 Bos taurus
1.14.17.1 1-Methylimidazole-2-thiol
-
 Bos taurus
1.14.17.1 p-Cresol
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 additional information
-
 additional information Km of ascorbate, tyramine and O2 as a function of pH and fumarate activation Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.1 additional information
-
 additional information KI as function of pH and fumarate activation Bos taurus