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Literature summary extracted from
- 3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity (1965), J. Biol. Chem., 240, 4763-4773.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.1 | CO | - |
Bos taurus |  |
| 1.14.17.1 | diethyldithiocarbamate | - |
Bos taurus | |
| 1.14.17.1 | KCN | - |
Bos taurus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.17.1 | Cu2+ | a copper protein | Bos taurus | |
| 1.14.17.1 | Cu2+ | enzyme contains a constant amount of Cu2+, 2 mol per mol of protein, and a variable amount of Cu2+, copper content is a linear function of the purity of the enzyme | Bos taurus | |
| 1.14.17.1 | Fe2+ | 0.0004 mM per mol of enzyme | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.17.1 | 290000 | - |
sedimentation equilibrium analysis, 5 mM potassium phosphate buffer, pH 6.8, 0.1 M NaCl | Bos taurus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.17.1 | - |
Bos taurus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.14.17.1 | dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O | mechanism | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.17.1 | adrenal gland | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.17.1 | 3.25 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.17.1 | 3,4-dihydroxyphenethylamine + ascorbate + O2 | - |
Bos taurus | noradrenaline + dehydroascorbate + H2O | norepinephrine | ? | |
| 1.14.17.1 | tyramine + ascorbate + O2 | - |
Bos taurus | octopamine + dehydroascorbate + H2O | - |
? | |
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Release 2023.1 (January 2023)
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