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Literature summary extracted from

  • Mancini, J.A.; Vickers, P.J.; O'Neill, G.P.; Boily, C.; Falgueyret, J.P.; Riendeau, D.
    Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs (1997), Mol. Pharmacol., 51, 52-60.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.99.1 medicine study of aspirin acetylated enzyme in order to inhibit prostaglandin synthesis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.1 S516M mutation mimics acetylation of Ser516, mutant still sensitive to most inhibitors, not: diclofenac, meclofenamic acid Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens
-
recombinant enzyme, product of COX-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonic acid + AH2 + 2 O2
-
Homo sapiens 15(R)-hydroxy-eicosatetraenoic acid + A + H2O product of aspirin acetylated enzyme or S516M mutant ?