Literature summary extracted from
Mancini, J.A.; Vickers, P.J.; O'Neill, G.P.; Boily, C.; Falgueyret, J.P.; Riendeau, D.
Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs (1997), Mol. Pharmacol., 51, 52-60.
Application
EC Number |
Application |
Comment |
Organism |
---|
1.14.99.1 |
medicine |
study of aspirin acetylated enzyme in order to inhibit prostaglandin synthesis |
Homo sapiens |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.14.99.1 |
S516M |
mutation mimics acetylation of Ser516, mutant still sensitive to most inhibitors, not: diclofenac, meclofenamic acid |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.14.99.1 |
Homo sapiens |
- |
recombinant enzyme, product of COX-2 |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.14.99.1 |
arachidonic acid + AH2 + 2 O2 |
- |
Homo sapiens |
15(R)-hydroxy-eicosatetraenoic acid + A + H2O |
product of aspirin acetylated enzyme or S516M mutant |
? |
|