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Literature summary extracted from
- Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme (1976), J. Biol. Chem., 251, 5575-5579.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | hemin | activates | Ovis aries |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.14.99.1 | diethyldithiocarbamate stabilizes | Ovis aries |
| 1.14.99.1 | ethylene glycol stabilizes | Ovis aries |
| 1.14.99.1 | flufenamate stabilizes | Ovis aries |
| 1.14.99.1 | glycerol stabilizes | Ovis aries |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | Iron | possibly contains heme and non-heme iron | Ovis aries | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 70000 | - |
x * 70000, SDS-PAGE in absence and presence of 2-mercaptoethanol | Ovis aries |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | Ovis aries | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.99.1 | - |
Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | seminal vesicle | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonic acid + AH2 + 2 O2 | - |
Ovis aries | 15-hydroperoxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid + A + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | ? | x * 70000, SDS-PAGE in absence and presence of 2-mercaptoethanol | Ovis aries |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 30 | - |
pH 8.0, 5 min, stable | Ovis aries |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | heme | enzyme contains a heme group | Ovis aries | |
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Release 2023.1 (January 2023)
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