EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.99.14 | 11alpha-hydroxyprogesterone | induced by | Aspergillus ochraceus | |
1.14.99.14 | nortestosterone | induced by | Aspergillus ochraceus | |
1.14.99.14 | progesterone | best inducer | Aspergillus ochraceus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.14 | progesterone + NADPH + O2 | Priestia megaterium | - |
11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? | |
1.14.99.14 | progesterone + NADPH + O2 | Aspergillus ochraceus | - |
11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? | |
1.14.99.14 | progesterone + NADPH + O2 | Aspergillus ochraceus NRRL 405 | - |
11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.99.14 | Aspergillus ochraceus | - |
- |
- |
1.14.99.14 | Aspergillus ochraceus NRRL 405 | - |
- |
- |
1.14.99.14 | Priestia megaterium | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.99.14 | mycelium | - |
Aspergillus ochraceus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.14 | 11alpha-hydroxyprogesterone + NADPH + O2 | - |
Aspergillus ochraceus | 6beta,11alpha-dihydroxyprogesterone | - |
? | |
1.14.99.14 | 11alpha-hydroxyprogesterone + NADPH + O2 | - |
Aspergillus ochraceus NRRL 405 | 6beta,11alpha-dihydroxyprogesterone | - |
? | |
1.14.99.14 | 19-nortestosterone + NADPH + O2 | - |
Aspergillus ochraceus | 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O | - |
? | |
1.14.99.14 | 19-nortestosterone + NADPH + O2 | - |
Aspergillus ochraceus NRRL 405 | 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O | - |
? | |
1.14.99.14 | additional information | 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity | Aspergillus ochraceus | ? | - |
? | |
1.14.99.14 | additional information | 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity | Aspergillus ochraceus NRRL 405 | ? | - |
? | |
1.14.99.14 | progesterone + NADPH + O2 | - |
Priestia megaterium | 11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? | |
1.14.99.14 | progesterone + NADPH + O2 | - |
Aspergillus ochraceus | 11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? | |
1.14.99.14 | progesterone + NADPH + O2 | - |
Aspergillus ochraceus NRRL 405 | 11alpha-hydroxyprogesterone + NADP+ + H2O | - |
? |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.99.14 | 30 | - |
loses potency at higher temperatures | Aspergillus ochraceus |