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Literature summary extracted from

  • Paltauf, F.; Holasek, A.
    Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine (1973), J. Biol. Chem., 248, 1609-1615.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.77 heat-lable factor of high molecular weight contained in the 100000 * g supernatant Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.77 1,10-phenanthroline
-
 Mesocricetus auratus
1.14.19.77 cholate weak inhibition Mesocricetus auratus
1.14.19.77 CN-
-
 Mesocricetus auratus
1.14.19.77 EDTA
-
 Mesocricetus auratus
1.14.19.77 menadione
-
 Mesocricetus auratus
1.14.19.77 NaN3
-
 Mesocricetus auratus
1.14.19.77 NEM
-
 Mesocricetus auratus
1.14.19.77 oleate weak inhibition Mesocricetus auratus
1.14.19.77 p-chloromercuribenzoate
-
 Mesocricetus auratus
1.14.19.77 taurocholate
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.77 microsome
-
 Mesocricetus auratus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.19.77 Mg2+
-
 Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.77 O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2 Mesocricetus auratus
-
 O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.77 Mesocricetus auratus
-
 adult animals of either sex
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.77 a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O mixed function oxidase Mesocricetus auratus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.77 small intestine mucosa
-
 Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.77 0.0000028
-
 microsomes plus soluble fraction, enzyme requires a heat-labile factor of high molecular weight contained in the soluble fraction Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.77 additional information no substrates: O-3-alkyl-2-acyl-sn-glycero-1-phosphoethanolamine, octadecylglycerol, octadecanal, octadecanol, stearic acid Mesocricetus auratus ?
-
 ?
1.14.19.77 additional information electron donors: NADPH or NADH Mesocricetus auratus ?
-
 ?
1.14.19.77 O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
-
 Mesocricetus auratus O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.19.77 37
-
 enzyme assay Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.77 7 8 phosphate buffer Mesocricetus auratus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.77 NADH
-
 Mesocricetus auratus
1.14.19.77 NADPH or NADH Mesocricetus auratus