Any feedback?
Literature summary extracted from
- Assay of microsomal heme oxygenase in liver and spleen (1978), Methods Enzymol., 52, 367-372.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | 1,10-phenanthroline | weak | Bos taurus |  |
| 1.14.14.18 | 1,10-phenanthroline | weak | Gallus gallus | |
| 1.14.14.18 | 1,10-phenanthroline | weak | Homo sapiens | |
| 1.14.14.18 | 1,10-phenanthroline | weak | Oryctolagus cuniculus | |
| 1.14.14.18 | 1,10-phenanthroline | weak | Rattus norvegicus | |
| 1.14.14.18 | 1,10-phenanthroline | weak | Sus scrofa | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Bos taurus | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Gallus gallus | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Homo sapiens | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Oryctolagus cuniculus | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Rattus norvegicus | |
| 1.14.14.18 | 2,2'-dipyridyl | weak | Sus scrofa | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Bos taurus | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Gallus gallus | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Homo sapiens | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| 1.14.14.18 | 4-hydroxymercuribenzoate | - |
Sus scrofa | |
| 1.14.14.18 | CO | strong inhibition | Bos taurus | |
| 1.14.14.18 | CO | strong inhibition | Gallus gallus | |
| 1.14.14.18 | CO | strong inhibition | Homo sapiens | |
| 1.14.14.18 | CO | strong inhibition | Oryctolagus cuniculus | |
| 1.14.14.18 | CO | strong inhibition | Rattus norvegicus | |
| 1.14.14.18 | CO | strong inhibition | Sus scrofa | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Bos taurus | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Gallus gallus | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Homo sapiens | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Oryctolagus cuniculus | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Rattus norvegicus | |
| 1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Sus scrofa | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Bos taurus | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Gallus gallus | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Homo sapiens | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Oryctolagus cuniculus | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Rattus norvegicus | |
| 1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Sus scrofa | |
| 1.14.14.18 | cysteine | - |
Bos taurus | |
| 1.14.14.18 | cysteine | - |
Gallus gallus | |
| 1.14.14.18 | cysteine | - |
Homo sapiens | |
| 1.14.14.18 | cysteine | - |
Oryctolagus cuniculus | |
| 1.14.14.18 | cysteine | - |
Rattus norvegicus | |
| 1.14.14.18 | cysteine | - |
Sus scrofa | |
| 1.14.14.18 | EDTA | weak | Bos taurus | |
| 1.14.14.18 | EDTA | weak | Gallus gallus | |
| 1.14.14.18 | EDTA | weak | Homo sapiens | |
| 1.14.14.18 | EDTA | weak | Oryctolagus cuniculus | |
| 1.14.14.18 | EDTA | weak | Rattus norvegicus | |
| 1.14.14.18 | EDTA | weak | Sus scrofa | |
| 1.14.14.18 | KCN | strong inhibition | Bos taurus | |
| 1.14.14.18 | KCN | strong inhibition | Gallus gallus | |
| 1.14.14.18 | KCN | strong inhibition | Homo sapiens | |
| 1.14.14.18 | KCN | strong inhibition | Oryctolagus cuniculus | |
| 1.14.14.18 | KCN | strong inhibition | Rattus norvegicus | |
| 1.14.14.18 | KCN | strong inhibition | Sus scrofa | |
| 1.14.14.18 | NaN3 | strong inhibition | Bos taurus | |
| 1.14.14.18 | NaN3 | strong inhibition | Gallus gallus | |
| 1.14.14.18 | NaN3 | strong inhibition | Homo sapiens | |
| 1.14.14.18 | NaN3 | strong inhibition | Oryctolagus cuniculus | |
| 1.14.14.18 | NaN3 | strong inhibition | Rattus norvegicus | |
| 1.14.14.18 | NaN3 | strong inhibition | Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.18 | 0.005 | - |
protoheme IX | enzyme from spleen and liver | Rattus norvegicus | |
| 1.14.14.18 | 0.0164 | - |
protoheme IX | enzyme from spleen | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.18 | microsome | - |
Gallus gallus | - |
- |
| 1.14.14.18 | microsome | - |
Homo sapiens | - |
- |
| 1.14.14.18 | microsome | - |
Rattus norvegicus | - |
- |
| 1.14.14.18 | microsome | - |
Sus scrofa | - |
- |
| 1.14.14.18 | microsome | - |
Bos taurus | - |
- |
| 1.14.14.18 | microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 200000 | - |
gel filtration | Rattus norvegicus |
| 1.14.14.18 | 200000 | - |
gel filtration | Sus scrofa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Gallus gallus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Homo sapiens | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Rattus norvegicus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Sus scrofa | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Bos taurus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Oryctolagus cuniculus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Bos taurus | - |
- |
- |
| 1.14.14.18 | Gallus gallus | - |
- |
- |
| 1.14.14.18 | Homo sapiens | - |
- |
- |
| 1.14.14.18 | Oryctolagus cuniculus | - |
- |
- |
| 1.14.14.18 | Rattus norvegicus | - |
- |
- |
| 1.14.14.18 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | brain | - |
Gallus gallus | - |
| 1.14.14.18 | brain | - |
Homo sapiens | - |
| 1.14.14.18 | brain | - |
Rattus norvegicus | - |
| 1.14.14.18 | brain | - |
Sus scrofa | - |
| 1.14.14.18 | brain | - |
Bos taurus | - |
| 1.14.14.18 | brain | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | heart | - |
Gallus gallus | - |
| 1.14.14.18 | heart | - |
Homo sapiens | - |
| 1.14.14.18 | heart | - |
Rattus norvegicus | - |
| 1.14.14.18 | heart | - |
Sus scrofa | - |
| 1.14.14.18 | heart | - |
Bos taurus | - |
| 1.14.14.18 | heart | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | kidney | - |
Gallus gallus | - |
| 1.14.14.18 | kidney | - |
Homo sapiens | - |
| 1.14.14.18 | kidney | - |
Rattus norvegicus | - |
| 1.14.14.18 | kidney | - |
Sus scrofa | - |
| 1.14.14.18 | kidney | - |
Bos taurus | - |
| 1.14.14.18 | kidney | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | liver | - |
Gallus gallus | - |
| 1.14.14.18 | liver | - |
Homo sapiens | - |
| 1.14.14.18 | liver | - |
Rattus norvegicus | - |
| 1.14.14.18 | liver | - |
Sus scrofa | - |
| 1.14.14.18 | liver | - |
Bos taurus | - |
| 1.14.14.18 | liver | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | lung | - |
Gallus gallus | - |
| 1.14.14.18 | lung | - |
Homo sapiens | - |
| 1.14.14.18 | lung | - |
Rattus norvegicus | - |
| 1.14.14.18 | lung | - |
Sus scrofa | - |
| 1.14.14.18 | lung | - |
Bos taurus | - |
| 1.14.14.18 | lung | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Gallus gallus | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Homo sapiens | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Rattus norvegicus | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Sus scrofa | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Bos taurus | - |
| 1.14.14.18 | macrophage | peritoneal, alveolar | Oryctolagus cuniculus | - |
| 1.14.14.18 | marrow | - |
Gallus gallus | - |
| 1.14.14.18 | marrow | - |
Homo sapiens | - |
| 1.14.14.18 | marrow | - |
Rattus norvegicus | - |
| 1.14.14.18 | marrow | - |
Sus scrofa | - |
| 1.14.14.18 | marrow | - |
Bos taurus | - |
| 1.14.14.18 | marrow | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | small intestine mucosa | - |
Gallus gallus | - |
| 1.14.14.18 | small intestine mucosa | - |
Homo sapiens | - |
| 1.14.14.18 | small intestine mucosa | - |
Rattus norvegicus | - |
| 1.14.14.18 | small intestine mucosa | - |
Sus scrofa | - |
| 1.14.14.18 | small intestine mucosa | - |
Bos taurus | - |
| 1.14.14.18 | small intestine mucosa | - |
Oryctolagus cuniculus | - |
| 1.14.14.18 | spleen | - |
Gallus gallus | - |
| 1.14.14.18 | spleen | - |
Homo sapiens | - |
| 1.14.14.18 | spleen | - |
Rattus norvegicus | - |
| 1.14.14.18 | spleen | - |
Sus scrofa | - |
| 1.14.14.18 | spleen | - |
Bos taurus | - |
| 1.14.14.18 | spleen | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | additional information | - |
assay procedure | Gallus gallus |
| 1.14.14.18 | additional information | - |
assay procedure | Homo sapiens |
| 1.14.14.18 | additional information | - |
assay procedure | Rattus norvegicus |
| 1.14.14.18 | additional information | - |
assay procedure | Sus scrofa |
| 1.14.14.18 | additional information | - |
assay procedure | Bos taurus |
| 1.14.14.18 | additional information | - |
assay procedure | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Gallus gallus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Homo sapiens | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Rattus norvegicus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Sus scrofa | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Bos taurus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Gallus gallus | ? | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Homo sapiens | ? | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Sus scrofa | ? | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Bos taurus | ? | - |
? | |
| 1.14.14.18 | methemoglobin + electron donor + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 37 | - |
assay at | Gallus gallus |
| 1.14.14.18 | 37 | - |
assay at | Homo sapiens |
| 1.14.14.18 | 37 | - |
assay at | Rattus norvegicus |
| 1.14.14.18 | 37 | - |
assay at | Sus scrofa |
| 1.14.14.18 | 37 | - |
assay at | Bos taurus |
| 1.14.14.18 | 37 | - |
assay at | Oryctolagus cuniculus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | - |
4 | several hours | Gallus gallus |
| 1.14.14.18 | - |
4 | several hours | Homo sapiens |
| 1.14.14.18 | - |
4 | several hours | Rattus norvegicus |
| 1.14.14.18 | - |
4 | several hours | Sus scrofa |
| 1.14.14.18 | - |
4 | several hours | Bos taurus |
| 1.14.14.18 | - |
4 | several hours | Oryctolagus cuniculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.18 | 7.4 | - |
- |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
