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Literature summary extracted from

  • Grolier, P.; Duszka, C.; Borel, P.; Alexandre-Gouabau, M.C.; Azais-Braesco, V.
    In vitro and in vivo inhibition of beta-carotene dioxygenase activity by canthaxanthin in rat intestine (1997), Arch. Biochem. Biophys., 348, 233-238.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.63 canthaxanthin mixed inhibition Rattus norvegicus
1.13.11.63 zeaxanthin non-competitive Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.63 0.0035
-
13-cis-beta-carotene
-
Rattus norvegicus
1.13.11.63 0.0057
-
all-trans-beta-carotene
-
Rattus norvegicus
1.13.11.63 0.0062
-
alpha-carotene
-
Rattus norvegicus
1.13.11.63 0.0067
-
beta-cryptoxanthin
-
Rattus norvegicus
1.13.11.63 0.0077
-
beta-apo-8'-carotenal
-
Rattus norvegicus
1.13.11.63 0.0085
-
beta-apo-8'-carotenal
-
Rattus norvegicus
1.13.11.63 0.0092
-
beta-apo-10'-carotenal
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 13-cis-beta-carotene + O2 11.4% of the activity with all-trans-beta-carotene Rattus norvegicus retinal
-
?
1.13.11.63 alpha-carotene + O2 8.2% of the activity with all-trans-beta-carotene Rattus norvegicus retinal
-
?
1.13.11.63 beta-apo-10'-carotenal + O2
-
Rattus norvegicus ?
-
r
1.13.11.63 beta-apo-8'-carotenal + O2
-
Rattus norvegicus ?
-
r
1.13.11.63 beta-cryptoxanthin + O2
-
Rattus norvegicus ?
-
r

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 betaCDIOX
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.63 0.0016
-
canthaxanthin
-
Rattus norvegicus
1.13.11.63 0.0078
-
zeaxanthin
-
Rattus norvegicus