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Literature summary extracted from

  • Redmond, T.M.; Gentleman, S.; Duncan, T.; Yu, S.; Wiggert, B.; Gantt, E.; Cunningham, F.X.
    Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase (2001), J. Biol. Chem., 276, 6560-6565.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 expression in Escherichia coli Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.63 0.06
-
 beta-carotene pH 8.0, 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.63 cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.63 63000
-
 x * 63859, calculated, x * 63000, SDS-PAGE Mus musculus
1.13.11.63 63859
-
 x * 63859, calculation from nucleotide sequence Mus musculus
1.13.11.63 63859
-
 x * 63859, calculated, x * 63000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Mus musculus crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors, enzyme may play a critical role in gastrulation retinal
-
 ?
1.13.11.63 beta-carotene + O2 Mus musculus enzyme may play a critical role in gastrulation retinal
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Mus musculus Q9JJS6
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.63 recombinant enzyme Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 embryo mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13 and 15 Mus musculus
-
1.13.11.63 intestine
-
 Mus musculus
-
1.13.11.63 kidney
-
 Mus musculus
-
1.13.11.63 liver
-
 Mus musculus
-
1.13.11.63 small intestine
-
 Mus musculus
-
1.13.11.63 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2
-
 Mus musculus retinal
-
 ?
1.13.11.63 beta-carotene + O2 crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors, enzyme may play a critical role in gastrulation Mus musculus retinal
-
 ?
1.13.11.63 beta-carotene + O2 enzyme may play a critical role in gastrulation Mus musculus retinal
-
 ?
1.13.11.63 beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.63 ? x * 63859, calculation from nucleotide sequence Mus musculus
1.13.11.63 ? x * 63859, calculated, x * 63000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 beta-carotene dioxygenase 1
-
 Mus musculus
1.13.11.63 beta-CD
-
 Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.63 0.0001
-
 beta-carotene
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.13.11.63 Mus musculus mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13, and 15 additional information

General Information

EC Number General Information Comment Organism
1.13.11.63 physiological function crucial enzyme in development and metabolism that governs the de novo entry of vitamin A from plant-derived precursors Mus musculus