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Literature summary extracted from

  • Berrie, J.R.; Williams, R.A.D.; Smith, K.E.
    Purification and characterization of progesterone hydroxylase, cytochrome P-450 from Streptomyces roseochromogenes ATCC 13400 (1997), Biochem. Soc. Trans., 25, 18S.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.99.4 coumarin hydroxylase activity is amplifiable by coumarin, increases 50% above that found constitutively Streptomyces roseochromogenus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.4 ketoconazole
-
 Streptomyces roseochromogenus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.4 65000
-
 PAGE, gel filtration Streptomyces roseochromogenus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.4 progesterone + NADPH + H+ + O2 Streptomyces roseochromogenus
-
 Testosterone acetate + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.4 Streptomyces roseochromogenus
-
 ATCC 13400
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.4
-
 Streptomyces roseochromogenus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.4 progesterone + NADPH + H+ + O2
-
 Streptomyces roseochromogenus Testosterone acetate + NADP+ + H2O
-
 ?
1.14.99.4 progesterone + NADPH + H+ + O2
-
 Streptomyces roseochromogenus 16alpha-hydroxyprogesterone + 2beta,16alpha-dihydroxyprogesterone + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.4 cytochrome P-450/monooxygenase
-
 Streptomyces roseochromogenus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.99.4 cytochrome P450
-
 Streptomyces roseochromogenus