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Literature summary extracted from
- Superoxide dismutases (1985), Top. Mol. Struct. Biol., 6, 121-156.
No PubMed abstract available
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.15.1.1 | - |
Escherichia coli |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.15.1.1 | additional information | naturally occuring hybrids between Fe-SOD and Mn-SOD, altered metal content | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.15.1.1 | perchlorate | competitive | Escherichia coli |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.15.1.1 | cytoplasm | - |
Escherichia coli | 5737 | - |
| 1.15.1.1 | cytoplasm | - |
Geobacillus stearothermophilus | 5737 | - |
| 1.15.1.1 | cytoplasm | - |
Photobacterium leiognathi | 5737 | - |
| 1.15.1.1 | cytoplasm | - |
Propionibacterium freudenreichii subsp. shermanii | 5737 | - |
| 1.15.1.1 | cytoplasm | - |
Caulobacter vibrioides | 5737 | - |
| 1.15.1.1 | cytoplasm | Cu,Zn-SOD | Saccharomyces cerevisiae | 5737 | - |
| 1.15.1.1 | mitochondrion | Mn-SOD | Saccharomyces cerevisiae | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.15.1.1 | Cu2+ | - |
Escherichia coli | |
| 1.15.1.1 | Cu2+ | - |
Geobacillus stearothermophilus | |
| 1.15.1.1 | Cu2+ | - |
Photobacterium leiognathi | |
| 1.15.1.1 | Cu2+ | - |
Caulobacter vibrioides | |
| 1.15.1.1 | Cu2+ | 2 mol of Cu per mol of enzyme | Saccharomyces cerevisiae | |
| 1.15.1.1 | Cu2+ | 2 mol of Cu per mol of enzyme | Bos taurus | |
| 1.15.1.1 | Iron | - |
Escherichia coli | |
| 1.15.1.1 | Iron | - |
Photobacterium leiognathi | |
| 1.15.1.1 | Iron | - |
Caulobacter vibrioides | |
| 1.15.1.1 | Mn2+ | - |
Escherichia coli | |
| 1.15.1.1 | Mn2+ | - |
Geobacillus stearothermophilus | |
| 1.15.1.1 | Mn2+ | - |
Photobacterium leiognathi | |
| 1.15.1.1 | Mn2+ | - |
Propionibacterium freudenreichii subsp. shermanii | |
| 1.15.1.1 | Mn2+ | - |
Caulobacter vibrioides | |
| 1.15.1.1 | Mn2+ | 4 mol per mol of enzyme | Saccharomyces cerevisiae | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Escherichia coli | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Saccharomyces cerevisiae | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Bos taurus | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Geobacillus stearothermophilus | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Photobacterium leiognathi | |
| 1.15.1.1 | additional information | enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron | Caulobacter vibrioides | |
| 1.15.1.1 | additional information | overview: metal content | Escherichia coli | |
| 1.15.1.1 | additional information | overview: metal content | Saccharomyces cerevisiae | |
| 1.15.1.1 | additional information | overview: metal content | Bos taurus | |
| 1.15.1.1 | additional information | overview: metal content | Geobacillus stearothermophilus | |
| 1.15.1.1 | additional information | overview: metal content | Photobacterium leiognathi | |
| 1.15.1.1 | additional information | overview: metal content | Caulobacter vibrioides | |
| 1.15.1.1 | Zn2+ | - |
Escherichia coli | |
| 1.15.1.1 | Zn2+ | - |
Geobacillus stearothermophilus | |
| 1.15.1.1 | Zn2+ | - |
Photobacterium leiognathi | |
| 1.15.1.1 | Zn2+ | - |
Caulobacter vibrioides | |
| 1.15.1.1 | Zn2+ | 2 mol of Zn2+ per mol of enzyme | Saccharomyces cerevisiae | |
| 1.15.1.1 | Zn2+ | 2 mol of Zn2+ per mol of enzyme | Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.15.1.1 | 31000 | - |
enzyme from cytoplasm | Saccharomyces cerevisiae |
| 1.15.1.1 | 32000 | 32500 | Cu,Zn-SOD | Bos taurus |
| 1.15.1.1 | 32000 | 32500 | Cu,Zn-SOD | Photobacterium leiognathi |
| 1.15.1.1 | 40000 | - |
Fe-SOD | Escherichia coli |
| 1.15.1.1 | 40000 | - |
Fe-SOD | Photobacterium leiognathi |
| 1.15.1.1 | 40000 | - |
Mn-SOD | Escherichia coli |
| 1.15.1.1 | 45000 | - |
- |
Geobacillus stearothermophilus |
| 1.15.1.1 | 96000 | - |
enzyme from mitochondria | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.15.1.1 | O2- + H+ | Escherichia coli | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Saccharomyces cerevisiae | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Bos taurus | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Geobacillus stearothermophilus | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Photobacterium leiognathi | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Propionibacterium freudenreichii subsp. shermanii | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Caulobacter vibrioides | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Bos taurus CuZn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Photobacterium leiognathi CuZn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Caulobacter vibrioides CuZn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Caulobacter vibrioides CB15 | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Escherichia coli Mn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Escherichia coli Fe-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Saccharomyces cerevisiae CuZn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Geobacillus stearothermophilus Mn-SOD | - |
O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | Saccharomyces cerevisiae Mn-SOD | - |
O2 + H2O2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.15.1.1 | Bos taurus | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Bos taurus CuZn-SOD | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Caulobacter vibrioides | - |
- |
- |
| 1.15.1.1 | Caulobacter vibrioides | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Caulobacter vibrioides CB15 | - |
- |
- |
| 1.15.1.1 | Caulobacter vibrioides CuZn-SOD | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Escherichia coli | - |
Mn-SOD | - |
| 1.15.1.1 | Escherichia coli | - |
Fe-SOD | - |
| 1.15.1.1 | Escherichia coli Fe-SOD | - |
Fe-SOD | - |
| 1.15.1.1 | Escherichia coli Mn-SOD | - |
Mn-SOD | - |
| 1.15.1.1 | Geobacillus stearothermophilus | - |
Mn-SOD | - |
| 1.15.1.1 | Geobacillus stearothermophilus Mn-SOD | - |
Mn-SOD | - |
| 1.15.1.1 | Photobacterium leiognathi | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Photobacterium leiognathi CuZn-SOD | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Propionibacterium freudenreichii subsp. shermanii | - |
structural intermediate between Mn-SOD and Fe-SOD | - |
| 1.15.1.1 | Saccharomyces cerevisiae | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Saccharomyces cerevisiae | - |
Mn-SOD | - |
| 1.15.1.1 | Saccharomyces cerevisiae CuZn-SOD | - |
Cu,Zn-SOD | - |
| 1.15.1.1 | Saccharomyces cerevisiae Mn-SOD | - |
Mn-SOD | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Escherichia coli | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Saccharomyces cerevisiae | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Bos taurus | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Geobacillus stearothermophilus | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Photobacterium leiognathi | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | mechanism | Caulobacter vibrioides | |
| 1.15.1.1 | 2 superoxide + 2 H+ = O2 + H2O2 | three-dimensional structure | Bos taurus |
Renatured (Commentary)
| EC Number | Renatured (Comment) | Organism |
|---|---|---|
| 1.15.1.1 | reconstitution of active enzyme after withdrawal of metal by either Mn or Fe yielding an active enzyme irrespective of the metal ion initially present | Photobacterium leiognathi |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.15.1.1 | erythrocyte | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.15.1.1 | O2- + H+ | - |
Escherichia coli | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Saccharomyces cerevisiae | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Bos taurus | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Geobacillus stearothermophilus | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Photobacterium leiognathi | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Propionibacterium freudenreichii subsp. shermanii | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Caulobacter vibrioides | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Bos taurus CuZn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Photobacterium leiognathi CuZn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Caulobacter vibrioides CuZn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Caulobacter vibrioides CB15 | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Escherichia coli Mn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Escherichia coli Fe-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Saccharomyces cerevisiae CuZn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Geobacillus stearothermophilus Mn-SOD | O2 + H2O2 | - |
? | |
| 1.15.1.1 | O2- + H+ | - |
Saccharomyces cerevisiae Mn-SOD | O2 + H2O2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.15.1.1 | dimer | - |
Escherichia coli |
| 1.15.1.1 | dimer | - |
Bos taurus |
| 1.15.1.1 | dimer | - |
Geobacillus stearothermophilus |
| 1.15.1.1 | dimer | - |
Photobacterium leiognathi |
| 1.15.1.1 | dimer | cytoplasmic enzyme | Saccharomyces cerevisiae |
| 1.15.1.1 | tetramer | mitochondrial enzyme | Saccharomyces cerevisiae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.15.1.1 | additional information | - |
pH-dependence, overview | Escherichia coli |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.15.1.1 | 20 | - |
perchlorate | - |
Escherichia coli | |
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