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Literature summary extracted from

  • Carlberg, I.C.; Sahlman, L.; Mannervik, B.
    The effect of 2,4,6-trinitrobenzenesulfonate on mercuric reductase, glutathione reductase and lipoamide dehydrogenase (1985), FEBS Lett., 180, 102-106.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.7 NADP+ stimulates Homo sapiens
1.8.1.7 NADPH substrate inhibition by excess of NADPH Homo sapiens
1.16.1.1 additional information 0.1 mM NADP+ stimulates the 2,4,6-trinitrobenzenesulfonate-dependent NADPH oxidation more than 10fold Pseudomonas aeruginosa
1.16.1.1 NADP+ strong stimulation of the reaction with 2,4,6-trinitrobenzenesulfonate and NADPH Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 2,4,6-Trinitrobenzenesulfonate 0.02 mM, 92% inhibition Homo sapiens
1.16.1.1 additional information no inhibition by 2,4,6-trinitrobenzenesulfonate; not inhibitory: 0.1 mM NADP+; not inhibitory: 100 microM 2,4,6-trinitrobenzenesulfonate Pseudomonas aeruginosa
1.16.1.1 NADPH substrate inhibition of the reaction with 2,4,6-trinitrobenzenesulfonate and NADPH Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-
1.16.1.1 Escherichia coli
-
-
-
1.16.1.1 Pseudomonas aeruginosa
-
-
-
1.16.1.1 Pseudomonas aeruginosa
-
 PAO9501
-
1.16.1.1 Pseudomonas aeruginosa PAO 9501
-
-
-
1.16.1.1 Pseudomonas aeruginosa PAO9501
-
 PAO9501
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH
-
 Homo sapiens glutathione + NADP+
-
 ?
1.16.1.1 2,4,6-trinitrobenzenesulfonate + NADPH
-
 Pseudomonas aeruginosa ? + NADP+
-
 ?
1.16.1.1 2,4,6-trinitrobenzenesulfonate + NADPH
-
 Pseudomonas aeruginosa PAO9501 ? + NADP+
-
 ?
1.16.1.1 2,4,6-trinitrobenzenesulfonate + NADPH
-
 Pseudomonas aeruginosa PAO 9501 ? + NADP+
-
 ?
1.16.1.1 Hg2+ + NADPH
-
 Escherichia coli Hg + NADP+ + H+
-
 ?
1.16.1.1 Hg2+ + NADPH
-
 Pseudomonas aeruginosa Hg + NADP+ + H+
-
 ?
1.16.1.1 Hg2+ + NADPH
-
 Pseudomonas aeruginosa PAO9501 Hg + NADP+ + H+
-
 ?
1.16.1.1 Hg2+ + NADPH
-
 Pseudomonas aeruginosa PAO 9501 Hg + NADP+ + H+
-
 ?
1.16.1.1 NADPH + Hg2+
-
 Pseudomonas aeruginosa NADP+ + Hg
-
 ?
1.16.1.1 NADPH + Hg2+
-
 Pseudomonas aeruginosa PAO9501 NADP+ + Hg
-
 ?
1.16.1.1 NADPH + Hg2+
-
 Pseudomonas aeruginosa PAO 9501 NADP+ + Hg
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.16.1.1 mercuric reductase
-
 Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.16.1.1 FAD
-
 Pseudomonas aeruginosa
1.16.1.1 NADPH
-
 Escherichia coli
1.16.1.1 NADPH
-
 Pseudomonas aeruginosa