EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | 2-mercaptoethanol | 25 mM, maximal activation, 70% of activity with dithiothreitol | Oryctolagus cuniculus | |
1.17.4.1 | dithioerythritol | 0.5 mM, maximal activation, 94% of activity with dithiothreitol | Oryctolagus cuniculus | |
1.17.4.1 | dithiothreitol | optimal in vitro activity with 10 mM, inhibition above | Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.1 | dithiothreitol | higher than 10 mM, activation below | Oryctolagus cuniculus | |
1.17.4.1 | Hydroxyurea | - |
Oryctolagus cuniculus | |
1.17.4.1 | UDP | inhibition of CDP reduction | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.4.1 | 0.0014 | - |
CDP | in the presence of 5'-adenylimidodiphosphate | Oryctolagus cuniculus | |
1.17.4.1 | 0.0023 | - |
CDP | in the presence of ATP | Oryctolagus cuniculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.1 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.17.4.1 | gel filtration, ATP-agarose, partial purification | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.17.4.1 | 0.0000045 | - |
partially purified enzyme, CDP reduction | Oryctolagus cuniculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.1 | CDP + reduced dithiothreitol | - |
Oryctolagus cuniculus | 2'-dCDP + oxidized dithiothreitol + H2O | - |
r | |
1.17.4.1 | CDP + reduced dithiothreitol | - |
Oryctolagus cuniculus | dCDP + oxidized dithiothreitol + H2O | - |
r | |
1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Oryctolagus cuniculus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.4.1 | 0.029 | - |
UDP | - |
Oryctolagus cuniculus | |
1.17.4.1 | 0.69 | - |
Hydroxyurea | - |
Oryctolagus cuniculus |