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Literature summary extracted from

  • Huszar, S.; Bacchetti, S.
    Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells (1981), J. Virol., 37, 580-588.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 ATP 3 mM, 65% inhibition Herpes simplex virus
1.17.4.1 dATP HSV type 2, 1 mM, 20% inhibition Herpes simplex virus
1.17.4.1 dTTP HSV type 2, 1 mM, 20% inhibition Herpes simplex virus
1.17.4.1 additional information not inhibited by dATP and dTTP Herpes simplex virus
1.17.4.1 pyridoxal 5'-phosphate 1 mM, 65% inhibition, 3 mM, 90% inhibition Herpes simplex virus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.4.1 additional information Mg2+ is not required for activity in vitro Herpes simplex virus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Herpes simplex virus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.1 streptomycin sulfate, ammonium sulfate, partial purification Herpes simplex virus

Storage Stability

EC Number Storage Stability Organism
1.17.4.1 -70°C, up to 8 months, no loss of activity Herpes simplex virus
1.17.4.1 4°C, at least 24 h, no loss of activity Herpes simplex virus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.17.4.1 50
-
 half-life: 2.5 min Herpes simplex virus