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Literature summary extracted from

  • Larsson, A.; Reichard, P.
    Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli (1966), J. Biol. Chem., 241, 2533-2539.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 dATP inhibition of CDP and UDP reduction is reversed by ATP; inhibition of CDP reduction; inhibition of UDP reduction Escherichia coli
1.17.4.1 GDP
-
 Escherichia coli
1.17.4.1 UDP
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.1 0.0015
-
 dTTP positive effector of CDP reduction Escherichia coli
1.17.4.1 0.07
-
 ATP positive effector of CDP reduction Escherichia coli
1.17.4.1 0.22
-
 UDP
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.4.1 Mg2+ subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Escherichia coli 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
1.17.4.1 UDP + reduced thioredoxin
-
 Escherichia coli 2'-deoxy-UDP + oxidized thioredoxin + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.1 0.007
-
 GDP competitive vs. CDP Escherichia coli
1.17.4.1 0.5
-
 UDP competitive vs. CDP Escherichia coli