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Literature summary extracted from

  • Yang, F.D.; Spanevello, R.A.; Celiker, I.; Hirschmann, R.; Rubin, H.; Cooperman, B.S.
    The carboxyl terminus heptapeptide of the R2 subunit of mammalian ribonucleotide reductase inhibits enzyme activity and can be used to purify the R1 subunit (1990), FEBS Lett., 272, 61-64.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 FTLDADF last seven amino acid residues of carboxyl terminus of the R2 subunit of mouse enzyme and its N-alpha-acetyl derivative inhibit thymus enzyme Bos taurus
1.17.4.1 N-alpha-acetyl-FTLDADF
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Bos taurus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.1 0.02
-
 N-alpha-acetyl-FTLDADF N-alpha-acetyl heptapeptide, identical to the last seven amino acids of R2 subunit C-terminus from mouse enzyme Bos taurus