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Literature summary extracted from
- Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1 (1984), J. Virol., 52, 981-983.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | ADP | competitive inhibition of CDP reduction | Herpes simplex virus |  |
| 1.17.4.1 | ATP | free ATP, 0.32 mM, 50% inhibition | Herpes simplex virus | |
| 1.17.4.1 | CDP | competitive inhibition of ADP reduction | Herpes simplex virus | |
| 1.17.4.1 | Mg2+ | uncomplexed Mg2+, 3.7 mM, 50% inhibition | Herpes simplex virus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.1 | 0.00049 | - |
CDP | - |
Herpes simplex virus | |
| 1.17.4.1 | 0.0078 | - |
ADP | - |
Herpes simplex virus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | Herpes simplex virus | - |
type 2, HSV-2 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.17.4.1 | HSV type 2 | Herpes simplex virus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.1 | 4.3 | - |
Herpes simplex virus type 2 enzyme, CDP reduction | Herpes simplex virus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.1 | ADP + thioredoxin | - |
Herpes simplex virus | 2'-dADP + thioredoxin disulfide + H2O | - |
r | |
| 1.17.4.1 | CDP + thioredoxin | - |
Herpes simplex virus | 2'-dCDP + thioredoxin disulfide + H2O | - |
r | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Herpes simplex virus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.1 | 0.00042 | - |
CDP | competitive inhibition of ADP reduction | Herpes simplex virus | |
| 1.17.4.1 | 0.011 | - |
ADP | competitive inhibition of CDP reduction | Herpes simplex virus | |
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