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Literature summary extracted from

  • carter, G.L.; Cory, J.G.
    Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase (1989), Adv. Enzyme Regul., 29, 123-139.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 additional information L1210 cells with resistance to specific nucleotide reductase inhibitors Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Mus musculus
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wild-type and reductase inhibitor resistant L1210 cell line
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 L-1210 cell L1210 cells resistant to specific ribonucleotide reductase inhibitors Mus musculus
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1.17.4.1 L-cell cell line Mus musculus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.4.1 additional information
-
extracts from hydroxyurea resistant cell line HU-7 exhibit a 13fold higher ADP reductase activity and a 5fold higher CDP reductase activity when compared to wild-type Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
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Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
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ir