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Literature summary extracted from

  • Spector, T.; Jones, T.E.
    Herpes simplex type 1 ribonucleotide reductase. Mechanism studies with inhibitors (1985), J. Biol. Chem., 260, 8694-8697.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole noncompetitive vs. CDP Herpes simplex virus
1.17.4.1 3,5-diamino-1H-1,2,4-triazole noncompetitive vs. CDP; trivial name guanazole Herpes simplex virus
1.17.4.1 4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone inactivation, half-life: 3 min Herpes simplex virus
1.17.4.1 additional information mechanism studied with inhibitors Herpes simplex virus
1.17.4.1 Periodate-oxidized inosine inactivation, 1 mM, half-life: 6 min Herpes simplex virus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Herpes simplex virus
-
type 1, HSV-1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
ir

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.1 1.1
-
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole derived from slope Herpes simplex virus
1.17.4.1 1.5
-
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole derived from intercept Herpes simplex virus
1.17.4.1 14
-
guanozole derived from intercept Herpes simplex virus
1.17.4.1 27
-
guanozole derived from slope Herpes simplex virus