Any feedback?
Literature summary extracted from
- Ribonucleotide reductase activity in intact mammalian cells: stimulation of enzyme activity by MgCl2, dithiothreitol, and several nucleotides (1984), Arch. Biochem. Biophys., 231, 9-16.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | ATP | stimulation of CDP reduction | Cricetulus griseus |  |
| 1.17.4.1 | ATP | stimulation of ADP reduction | Cricetulus griseus | |
| 1.17.4.1 | dCTP | stimulation of CDP and ADP reduction | Cricetulus griseus | |
| 1.17.4.1 | dGTP | stimulation of CDP reduction | Cricetulus griseus | |
| 1.17.4.1 | dithiothreitol | required for optimal activity | Cricetulus griseus | |
| 1.17.4.1 | GTP | stimulation of CDP and ADP reduction | Cricetulus griseus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.1 | 0.021 | - |
CDP | in the presence of 1.5 mM ATP | Cricetulus griseus | |
| 1.17.4.1 | 0.033 | - |
CDP | in the presence of 3.6 mM dCTP | Cricetulus griseus | |
| 1.17.4.1 | 0.095 | - |
ADP | optimum dGTP concentration | Cricetulus griseus | |
| 1.17.4.1 | 0.2 | - |
ADP | in the presence of 0.2 mM GTP | Cricetulus griseus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.1 | Mg2+ | stimulates CDP but not ADP reduction | Cricetulus griseus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | Cricetulus griseus | - |
Chinese hamster overy cells | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.4.1 | CHO cell | - |
Cricetulus griseus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.1 | ADP + reduced dithiothreitol | - |
Cricetulus griseus | 2'-dADP + oxidized dithiothreitol + H2O | - |
r | |
| 1.17.4.1 | CDP + reduced dithiothreitol | - |
Cricetulus griseus | 2'-dCDP + oxidized dithiothreitol + H2O | - |
r | |
| 1.17.4.1 | ribonucleoside diphosphate + reduced thioredoxin | - |
Cricetulus griseus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
