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Literature summary extracted from

  • Elford, H.L.; Van't Riet, B.; Wampler, G.L.; Lin, A.L.; Elford, R.M.
    Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents (1981), Adv. Enzyme Regul., 19, 151-168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 2,3,4-Trihydroxybenzamide
-
 Homo sapiens
1.17.4.1 2,3,4-trihydroxybenzohydroxamic acid 0.0035 mM, 50% inhibition Homo sapiens
1.17.4.1 2,3-dihydroxybenzohydroxamic acid 0.008 mM, 50% inhibition Homo sapiens
1.17.4.1 2,4-dichlorobenzohydroxamic acid 0.45 mM, 50% inhibition Homo sapiens
1.17.4.1 2,4-dihydroxybenzohydroxamic acid 0.3 mM, 50% inhibition Homo sapiens
1.17.4.1 2,5-dihydroxybenzohydroxamic acid 0.2 mM, 50% inhibition Homo sapiens
1.17.4.1 2,6-dihydroxybenzohydroxamic acid 0.1 mM, 50% inhibition Homo sapiens
1.17.4.1 2-aminobenzohydroxamic acid 0.12 mM, 50% inhibition Homo sapiens
1.17.4.1 2-hydroxy-3-methylbenzohydroxamic acid 0.15 mM, 50% inhibition Homo sapiens
1.17.4.1 2-hydroxy-4-aminobenzohydroxamic acid 0.2 mM, 50% inhibition Homo sapiens
1.17.4.1 2-hydroxybenzohydroxamic acid 0.15 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4,5-Trihydroxybenzamide
-
 Homo sapiens
1.17.4.1 3,4,5-Trihydroxybenzohydroxamic acid 0.01 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4,5-Trihydroxybenzoic acid
-
 Homo sapiens
1.17.4.1 3,4,5-trimethoxybenzohydroxamic acid 0.1 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4-diaminobenzohydroxamic acid 0.04 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4-dichlorobenzohydroxamic acid 0.3 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4-Dihydroxybenzamide
-
 Homo sapiens
1.17.4.1 3,4-dihydroxybenzohydroxamic acid 0.03 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4-dimethoxybenzohydroxamic acid 0.3 mM, 50% inhibition Homo sapiens
1.17.4.1 3,4-dimethylbenzohydroxamic acid 0.3 mM, 50% inhibition Homo sapiens
1.17.4.1 3,5-dihydroxybenzohydroxamic acid 0.4 mM, 50% inhibition Homo sapiens
1.17.4.1 3-aminobenzohydroxamic acid 0.35 mM, 50% inhibition Homo sapiens
1.17.4.1 3-hydroxybenzohydroxamic acid 0.35 mM, 50% inhibition Homo sapiens
1.17.4.1 4-aminobenzohydroxamic acid 0.15 mM, 50% inhibition Homo sapiens
1.17.4.1 4-dimethylaminobenzohydroxamic acid 0.5 mM, 50% inhibition Homo sapiens
1.17.4.1 4-hydroxybenzohydroxamic acid 0.30 mM, 50% inhibition Homo sapiens
1.17.4.1 4-methoxybenzohydroxamic acid 0.5 mM, 50% inhibition Homo sapiens
1.17.4.1 4-methylaminobenzohydroxamic acid 0.33 mM, 50% inhibition Homo sapiens
1.17.4.1 4-nitrobenzohydroxamic acid 0.5 mM, 50% inhibition Homo sapiens
1.17.4.1 Acetohydroxamic acid 1 mM, 50% inhibition Homo sapiens
1.17.4.1 benzohydroxamic acid 0.4 mM, 50% inhibition Homo sapiens
1.17.4.1 Hydroxyurea 0.5 mM, 50% inhibition Homo sapiens
1.17.4.1 Methyl 3,4,5-trihydroxybenzoate
-
 Homo sapiens
1.17.4.1 N-Methyl 3,4,5-trihydroxybenzamide
-
 Homo sapiens
1.17.4.1 nicotinohydroxamic acid 0.8 mM, 50% inhibition Homo sapiens
1.17.4.1 phenylacetohydroxamic acid 1 mM, 50% inhibition Homo sapiens
1.17.4.1 picolinohydroxamic acid 0.5 mM, 50% inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Homo sapiens
-
 HeLa cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Homo sapiens 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir