Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kjoller Larsen, I.; Sj๖berg, B.M.; Thelander, L.
    Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues (1982), Eur. J. Biochem., 125, 75-81.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 1-methyl-1-hydroxyurea 10 mM, 55% inhibition Escherichia coli
1.17.4.1 2,3,4-trihydroxybenzohydroxamic acid 0.009 mM, 50% inhibition, reversible Bos taurus
1.17.4.1 2,3,4-trihydroxybenzohydroxamic acid 0.012 mM, 50% inhibition, hydroxyurea-resistant cells Mus musculus
1.17.4.1 3,4-dihydroxybenzohydroxamic acid 0.033 mM, 50% inhibition, reversible Bos taurus
1.17.4.1 3,4-dihydroxybenzohydroxamic acid 2.5 mM, 50% inhibition Escherichia coli
1.17.4.1 3,4-dihydroxybenzohydroxamic acid 0.3 mM, 50% inhibition Tequatrovirus T4
1.17.4.1 3-methyl-1-hydroxyurea 10 mM, 57% inhibition Escherichia coli
1.17.4.1 formohydroxamic acid 10 mM, 43% inhibition Escherichia coli
1.17.4.1 hydroxylamine 10 mM, complete inhibition Escherichia coli
1.17.4.1 Hydroxyurea
-
 Bos taurus
1.17.4.1 Hydroxyurea 10 mM, complete inhibition, 0.3 mM, 50% inhibition Escherichia coli
1.17.4.1 Hydroxyurea
-
 Mus musculus
1.17.4.1 Hydroxyurea 0.025 mM, 50% inhibition Tequatrovirus T4
1.17.4.1 N,2,3,4-tetrahydroxybenzamide 0.012 mM, 50% inhibition, reversible Bos taurus
1.17.4.1 N-hydroxyguanidine 10 mM, 89% inhibition Escherichia coli
1.17.4.1 N-hydroxyurethane 10 mM, 66% inhibition Escherichia coli
1.17.4.1 N-Methylhydroxylamine 10 mM, 94% inhibition Escherichia coli
1.17.4.1 Polyhydroxybenzohydroxamic acid
-
 Escherichia coli
1.17.4.1 Polyhydroxybenzohydroxamic acid
-
 Mus musculus
1.17.4.1 Polyhydroxybenzohydroxamic acid
-
 Tequatrovirus T4

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Bos taurus
-
-
-
1.17.4.1 Escherichia coli
-
-
-
1.17.4.1 Mus musculus
-
-
-
1.17.4.1 Tequatrovirus T4
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Escherichia coli 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Bos taurus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Tequatrovirus T4 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir