Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Moore, E.C.; Hurlbert, R.B.
    Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors (1966), J. Biol. Chem., 241, 4802-4809.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.1 ATP reduction of CDP and UDP requires 1-2 mM ATP Rattus norvegicus
1.17.4.1 ATP further stimulation of dTTP activated GDP reduction Rattus norvegicus
1.17.4.1 dATP stimulation of GDP reduction Rattus norvegicus
1.17.4.1 dGTP required for ADP reduction, maximal activity with 0.01 mM dGTP Rattus norvegicus
1.17.4.1 dTTP stimulation of GDP reduction Rattus norvegicus
1.17.4.1 dTTP absolutely required for GDP reduction, less than 10% activity in the absence of dTTP, maximal stimulation with 0.001-0.1 mM dTTP in the absence of ATP and 0.1-1 mM in the presence of ATP, inhibition above Rattus norvegicus
1.17.4.1 dTTP required for ADP reduction Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 dATP inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction Rattus norvegicus
1.17.4.1 dGTP inhibition of CDP reduction; inhibition of GDP reduction; inhibition of UDP reduction Rattus norvegicus
1.17.4.1 dTTP inhibition of CDP reduction; inhibition of UDP reduction Rattus norvegicus
1.17.4.1 dUTP inhibition of: CDP reduction, UDP reduction Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.1 additional information
-
 additional information effect of different nucleoside triphosphates on Km Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Rattus norvegicus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir