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Literature summary extracted from

  • Suto, R.K.; Poppe, L.; Retey, J.; Finke, R.G.
    Ribonucleoside triphosphate reductase from Lactobacillus leichmannii: Kinetic evaluation of a series of adenosylcobalamin competitive inhibitors, [omega-(adenosin-5'-O-yl)alkyl]cobalamins, which mimic the post Co-C homolysis intermediate (1999), Bioorg. Chem., 27, 451-462.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.2 5'-deoxyadenosylcobalamin
-
 Lactobacillus leichmannii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.2 overexpressed in Escherichia coli Lactobacillus leichmannii

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.2 cob(II)alamin
-
 Lactobacillus leichmannii
1.17.4.2 cyanocobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [3-(adenosin-5'-O-yl)propyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [4-(adenosin-5'-O-yl)butyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [5-(adenosin-5'-O-yl)pentyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [6-(adenosin-5'-O-yl)hexyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [7-(adenosin-5'-O-yl)heptyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 [omega-(adenosin-5'-O-yl)alkyl]cobalamin
-
 Lactobacillus leichmannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O Lactobacillus leichmannii
-
 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.2 Lactobacillus leichmannii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.2 from overexpressing Escherichia coli cells Lactobacillus leichmannii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin
-
 Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
 r
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O
-
 Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.17.4.2 RTPR
-
 Lactobacillus leichmannii

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.2 coenzyme B12 adenosylcobalamin Lactobacillus leichmannii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.2 0.0077
-
 [5-(adenosin-5'-O-yl)pentyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0128
-
 [7-(adenosin-5'-O-yl)heptyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0143
-
 cob(II)alamin + adenosine Lactobacillus leichmannii
1.17.4.2 0.0189
-
 [4-(adenosin-5'-O-yl)butyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0208
-
 cob(II)alamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0246
-
 [6-(adenosin-5'-O-yl)hexyl]cobalamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0426
-
 cyanocobalamin
-
 Lactobacillus leichmannii
1.17.4.2 0.0558
-
 [3-(adenosin-5'-O-yl)propyl]cobalamin
-
 Lactobacillus leichmannii