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Literature summary extracted from
- Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase (2002), J. Biol. Chem., 277, 41086-41093.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.3.5 | farnesal | non-competitive versus farnesyl-L-cysteine | Homo sapiens |  |
| 1.8.3.5 | farnesol | non-competitive versus farnesyl-L-cysteine | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.3.5 | 0.003 | - |
farnesyl-L-cysteine | - |
Homo sapiens | |
| 1.8.3.5 | 0.05 | - |
O2 | Km below | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.3.5 | S-prenyl-L-cysteine + O2 + H2O | Homo sapiens | kinetic mechanism, enzyme transfers the pro-S hydride of the farnesylcysteine to FAD | prenal + L-cysteine + H2O2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.3.5 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.3.5 | farnesyl-L-cysteine + O2 + H2O | - |
Homo sapiens | farnesal + L-cysteine + H2O2 | - |
? | |
| 1.8.3.5 | S-prenyl-L-cysteine + O2 + H2O | - |
Homo sapiens | prenal + L-cysteine + H2O2 | - |
? | |
| 1.8.3.5 | S-prenyl-L-cysteine + O2 + H2O | kinetic mechanism, enzyme transfers the pro-S hydride of the farnesylcysteine to FAD | Homo sapiens | prenal + L-cysteine + H2O2 | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.3.5 | 25 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.3.5 | 0.000133 | - |
farnesyl-L-cysteine | - |
Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.3.5 | 7.4 | 7.7 | assay at, depending on type of assay | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.3.5 | FAD | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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