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Literature summary extracted from

  • Beigneux, A.; Withycombe, S.K.; Digits, J.A.; Tschantz, W.R.; Weinbaum, C.A.; Griffey, S.M.; Bergo, M.; Casey, P.J.; Young, S.G.
    Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver (2002), J. Biol. Chem., 277, 38358-38363.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.3.5
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.3.5 S-prenyl-L-cysteine + O2 + H2O Mus musculus physiologic role in cleaving prenylcysteines in mammals, cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid prenal + L-cysteine + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.5 Mus musculus Q9CQF9 mouse, wild type and knockout mutants
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.3.5 brain
-
 Mus musculus
-
1.8.3.5 heart
-
 Mus musculus
-
1.8.3.5 kidney
-
 Mus musculus
-
1.8.3.5 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.5 farnesyl-L-cysteine + O2 + H2O
-
 Mus musculus farnesal + L-cysteine + H2O2
-
 ?
1.8.3.5 geranylgeranyl-L-cysteine + O2 + H2O
-
 Mus musculus geranylgeranal + L-cysteine + H2O2
-
 ?
1.8.3.5 S-prenyl-L-cysteine + O2 + H2O
-
 Mus musculus prenal + L-cysteine + H2O2
-
 ?
1.8.3.5 S-prenyl-L-cysteine + O2 + H2O physiologic role in cleaving prenylcysteines in mammals, cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid Mus musculus prenal + L-cysteine + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.3.5 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.3.5 7.7
-
 assay at Mus musculus