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Literature summary extracted from

  • Miyazaki, M.; Kim, H.J.; Man, W.C.; Ntambi, J.M.
    Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol (2001), J. Biol. Chem., 276, 39455-39461.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.19.1 medicine potential use of SCD1 as a target in the treatment of some eye diseases Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 additional information Mus musculus rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids ?
-
 ?
1.14.19.1 palmitoyl-CoA + AH2 + O2 Mus musculus
-
 palmitoleoyl-CoA + A + H2O
-
 ?
1.14.19.1 stearoyl-CoA + AH2 + O2 Mus musculus
-
 oleoyl-CoA + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O existence of three highly homologous isoforms: SCD1, SCD2 and SCD3 which show different substrate specificities, here SCD1 is mainly analysed Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 adipose contains high amounts Mus musculus
-
1.14.19.1 brain
-
 Mus musculus
-
1.14.19.1 eye ball Mus musculus
-
1.14.19.1 gland contains high amounts Mus musculus
-
1.14.19.1 liver
-
 Mus musculus
-
1.14.19.1 spleen
-
 Mus musculus
-
1.14.19.1 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 additional information SCD2 and SCD3 preferentially utilize palmitoyl-CoA Mus musculus ?
-
 ?
1.14.19.1 additional information rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids Mus musculus ?
-
 ?
1.14.19.1 palmitoyl-CoA + AH2 + O2
-
 Mus musculus palmitoleoyl-CoA + A + H2O
-
 ?
1.14.19.1 palmitoyl-CoA + NADH + O2
-
 Mus musculus palmitoleoyl-CoA + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + AH2 + O2
-
 Mus musculus oleoyl-CoA + A + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + O2 preferred substrate for SCD1 Mus musculus oleoyl-CoA + NAD+ + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.19.1 23
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.1 7.2
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 NADH
-
 Mus musculus