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Literature summary extracted from

  • Jeffcoat, R.
    The physiological role and control of mammalian fatty acyl-coenzyme A desaturases (1977), Biochem. Soc. Trans., 5, 811-818.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.1 bovine serum albumin stimulates activity in the microsomal fraction Rattus norvegicus
1.14.19.1 Insulin causes 5fold increace of activity Gallus gallus
1.14.19.1 protein non-substrate soluble cytosolic protein stimulates Rattus norvegicus
1.14.19.1 stearoyl-CoA-binding protein stimulates activity in the crude microsomal fraction Rattus norvegicus
1.14.19.1 thyroxine
-
 Gallus gallus
1.14.19.1 triiodothyronine
-
 Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 cycloheximide
-
 Gallus gallus
1.14.19.1 ethyl linoleate
-
 Rattus norvegicus
1.14.19.1 ethyl palmitate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 endoplasmic reticulum
-
 Gallus gallus 5783
-
1.14.19.1 endoplasmic reticulum bound Rattus norvegicus 5783
-
1.14.19.1 microsome membrane bound Gallus gallus
-
-
1.14.19.1 microsome membrane bound Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.19.1 Fe2+
-
 Gallus gallus
1.14.19.1 Fe2+ contains one atom of non-heme iron per enzyme molecule, catalytic function Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.1 53000
-
 x * 53000 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearate + AH2 + O2 Rattus norvegicus biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate oleate + A + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Gallus gallus
-
 embryo
-
1.14.19.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.19.1 partially Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O introduction of double bonds at fixed positions from the carboxyl group of the fatty acid. D-hydrogen atoms are removed during desaturation. Mixed-function oxidase, acting via hydroxy acid intermediates. Acetyl-CoA desaturase, carboxylase and fatty acid synthetase are all controlled together as a unit and influenced by dietary components Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
-
 Gallus gallus
-
1.14.19.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 heptadecanoate + AH2 + O2 low activity Rattus norvegicus ?
-
 ?
1.14.19.1 nonadecanoate + AH2 + O2 low activity Rattus norvegicus ?
-
 ?
1.14.19.1 stearate + AH2 + O2 maximum activity Rattus norvegicus oleate + A + 2 H2O
-
 ?
1.14.19.1 stearate + AH2 + O2 biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate Rattus norvegicus oleate + A + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.1 ?
-
 Gallus gallus
1.14.19.1 ? x * 53000 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 flavin flavin-containing NADH-cytochrome b5 reductase (EC 1.6.2.2.) Rattus norvegicus
1.14.19.1 heme heme-containing cytochrome b5 Rattus norvegicus
1.14.19.1 NADH
-
 Gallus gallus
1.14.19.1 NADH
-
 Rattus norvegicus