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Literature summary extracted from

  • Chudomelka, P.J.; Ramaley, R.F.; Murrin, L.C.
    Histidine decarboxylase from rat and rabbit brain: partial purification and characterization (1990), Neurochem. Res., 15, 17-24.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 alpha-Fluoromethylhistidine
-
 Oryctolagus cuniculus
4.1.1.22 alpha-Fluoromethylhistidine
-
 Rattus norvegicus
4.1.1.22 CoCl2
-
 Oryctolagus cuniculus
4.1.1.22 CoCl2
-
 Rattus norvegicus
4.1.1.22 NiCl2
-
 Oryctolagus cuniculus
4.1.1.22 NiCl2
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 0.078
-
 L-His
-
 Rattus norvegicus
4.1.1.22 0.12
-
 L-His
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Oryctolagus cuniculus
-
-
-
4.1.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22 partial Rattus norvegicus
4.1.1.22 partial Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 brain
-
 Rattus norvegicus
-
4.1.1.22 brain
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 additional information
-
-
 Rattus norvegicus
4.1.1.22 additional information
-
-
 Oryctolagus cuniculus

Storage Stability

EC Number Storage Stability Organism
4.1.1.22 -70°C, 94% of the original activity in the fresh preparation Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His
-
 Rattus norvegicus Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Oryctolagus cuniculus Histamine + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.22 45
-
-
 Rattus norvegicus
4.1.1.22 45
-
-
 Oryctolagus cuniculus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.22 55
-
 denaturation of enzyme activity Rattus norvegicus
4.1.1.22 55
-
 denaturation of enzyme activity Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 7.2 8
-
 Rattus norvegicus
4.1.1.22 7.2 8
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.22 7 9 pH 7.0: about 85% of maximal activity, pH 9.0: about 70% of maximal activity Oryctolagus cuniculus
4.1.1.22 7 9 about 45% of maximal activity at pH 7.0 and at pH 9.0 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate required Rattus norvegicus
4.1.1.22 pyridoxal 5'-phosphate required Oryctolagus cuniculus