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Literature summary extracted from

  • Guirard, B.M.; Snell, E.E.
    Purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylase from Klebsiella planticola and Enterobacter aerogenes (1987), J. Bacteriol., 169, 3963-3968.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 alpha-Fluoromethylhistidine
-
 Klebsiella aerogenes
4.1.1.22 alpha-Fluoromethylhistidine
-
 Morganella morganii
4.1.1.22 alpha-Fluoromethylhistidine
-
 Raoultella planticola
4.1.1.22 alpha-Methylhistidine
-
 Klebsiella aerogenes
4.1.1.22 alpha-Methylhistidine
-
 Morganella morganii
4.1.1.22 alpha-Methylhistidine
-
 Raoultella planticola
4.1.1.22 carnosine
-
 Klebsiella aerogenes
4.1.1.22 carnosine
-
 Morganella morganii
4.1.1.22 carnosine
-
 Raoultella planticola
4.1.1.22 Cyanoborohydride
-
 Morganella morganii
4.1.1.22 dithiothreitol
-
 Klebsiella aerogenes
4.1.1.22 dithiothreitol
-
 Morganella morganii
4.1.1.22 dithiothreitol
-
 Raoultella planticola
4.1.1.22 Histidine methyl ester
-
 Klebsiella aerogenes
4.1.1.22 Histidine methyl ester
-
 Raoultella planticola
4.1.1.22 Hydrazine sulfate
-
 Klebsiella aerogenes
4.1.1.22 Hydrazine sulfate
-
 Raoultella planticola

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 1.1
-
 L-His
-
 Morganella morganii
4.1.1.22 2.2
-
 L-His
-
 Klebsiella aerogenes
4.1.1.22 2.4
-
 L-His
-
 Raoultella planticola

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 42500
-
 2 * and 4 * 42500, SDS-PAGE Raoultella planticola
4.1.1.22 42500
-
 4 * and 2 * 42500, SDS-PAGE Raoultella planticola
4.1.1.22 50000
-
 2 * 50000, SDS-PAGE Klebsiella aerogenes

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Klebsiella aerogenes
-
-
-
4.1.1.22 Morganella morganii
-
-
-
4.1.1.22 Morganella morganii AM-15
-
-
-
4.1.1.22 Raoultella planticola
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Klebsiella aerogenes
4.1.1.22
-
 Raoultella planticola

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 121
-
-
 Klebsiella aerogenes
4.1.1.22 123
-
-
 Raoultella planticola

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His
-
 Klebsiella aerogenes Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Morganella morganii Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Raoultella planticola Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Morganella morganii AM-15 Histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 dimer 2 * 50000, SDS-PAGE Klebsiella aerogenes
4.1.1.22 dimer 2 * and 4 * 42500, SDS-PAGE Raoultella planticola
4.1.1.22 tetramer
-
 Morganella morganii
4.1.1.22 tetramer 4 * and 2 * 42500, SDS-PAGE Raoultella planticola

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.5
-
-
 Klebsiella aerogenes
4.1.1.22 6.5
-
-
 Morganella morganii
4.1.1.22 6.5
-
-
 Raoultella planticola

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Morganella morganii
4.1.1.22 pyridoxal 5'-phosphate contains 1 mol of pyridoxal 5'-phosphate per mol of subunit Klebsiella aerogenes
4.1.1.22 pyridoxal 5'-phosphate contains 1 mol of pyridoxal 5'-phosphate per mol of subunit Raoultella planticola