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Literature summary extracted from

  • Rescei, P.A.; Moore, W.M.; Snell, E.E.
    Pyruvoyl-dependent histidine decarboxylase from Clostridium perfringens and Lactobacillus buchneri (1983), J. Biol. Chem., 258, 439-444.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 pyruvate pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine Lentilactobacillus buchneri
4.1.1.22 pyruvate pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine Clostridium perfringens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 Cyanoborohydride NaCNBH3 Clostridium perfringens
4.1.1.22 histamine
-
 Clostridium perfringens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 0.3
-
 L-His
-
 Clostridium perfringens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.22 CaCl2 maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens
4.1.1.22 K2SO4 maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens
4.1.1.22 KCl maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens
4.1.1.22 MgCl2 maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens
4.1.1.22 NaBr maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens
4.1.1.22 NaCl maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 Clostridium perfringens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 9000
-
 6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE Clostridium perfringens
4.1.1.22 27000
-
 6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE Clostridium perfringens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Clostridium perfringens
-
-
-
4.1.1.22 Lentilactobacillus buchneri
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Clostridium perfringens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 7
-
-
 Clostridium perfringens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His
-
 Lentilactobacillus buchneri Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Clostridium perfringens Histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 dodecamer 6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE Clostridium perfringens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 4.5
-
-
 Clostridium perfringens