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Literature summary extracted from

  • Savany, A.; Cronenberger, L.
    Properties of histidine decarboxylase from rat gastric mucosa (1982), Eur. J. Biochem., 123, 593-599.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 2-Hydroxy-5-nitrobenzylbromide
-
 Rattus norvegicus
4.1.1.22 Co2+ 0.1 mM, 20% decrease of activity Rattus norvegicus
4.1.1.22 Cu2+ 0.1 mM, strong inhibition Rattus norvegicus
4.1.1.22 Cys
-
 Rattus norvegicus
4.1.1.22 dithiothreitol
-
 Rattus norvegicus
4.1.1.22 Hg2+ 0.1 mM, strong inhibition Rattus norvegicus
4.1.1.22 histamine at high concentrations Rattus norvegicus
4.1.1.22 NEM
-
 Rattus norvegicus
4.1.1.22 Ni2+ 0.1 mM, 15% decrease of activity Rattus norvegicus
4.1.1.22 p-hydroxymercuribenzoate
-
 Rattus norvegicus
4.1.1.22 pyridoxal 5'-phosphate non-competitive inhibition with respect to His, at high concentrations Rattus norvegicus
4.1.1.22 reduced glutathione
-
 Rattus norvegicus
4.1.1.22 Semicarbazide
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.22 Fe3+ 0.1 mM, enhances activity by 7-8% Rattus norvegicus
4.1.1.22 Mn2+ 0.1 mM, enhances activity by 7-8% Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 gastric mucosa
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His strictly specific for L-His Rattus norvegicus Histamine + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.22 56
-
-
 Rattus norvegicus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.1.1.22 47 60 47°C: about 50% of maximal activity, 60°C: about 75% of maximal activity, no activity detectable at 65°C Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.22 45
-
 stable for at least 30 min, without pyridoxal 5'-phosphate Rattus norvegicus
4.1.1.22 50
-
 40% loss of activity after 30 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate Rattus norvegicus
4.1.1.22 55
-
 50% loss of activity in 13 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate Rattus norvegicus
4.1.1.22 57
-
 50% loss of activity in 4 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate Rattus norvegicus
4.1.1.22 60
-
 50% loss of activity in 2 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate Rattus norvegicus
4.1.1.22 64
-
 50% loss of activity in 30 s, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.6
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate required Rattus norvegicus
4.1.1.22 pyridoxal 5'-phosphate tightly bound to the apoenzyme. Non-competitive inhibition at high concentrations Rattus norvegicus