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Literature summary extracted from

  • Rosner, A.
    Control of lysine biosynthesis in Bacillis subtilis: inhibition of diaminopimelate decarboxylase by lysine (1975), J. Bacteriol., 121, 20-28.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.20 EDTA activates Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.20 D-Lysine
-
 Bacillus subtilis
4.1.1.20 L-2,4-diaminobutyrate
-
 Bacillus subtilis
4.1.1.20 L-lysine involved in sequential feedback inhibition, pH-dependent Bacillus subtilis
4.1.1.20 L-ornithine
-
 Bacillus subtilis
4.1.1.20 L-S-aminoethylcysteine
-
 Bacillus subtilis
4.1.1.20 n-butylamine
-
 Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.20 1
-
 meso-2,6-diaminoheptanedioate
-
 Bacillus subtilis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.20 K+ activates Bacillus subtilis
4.1.1.20 Na+ activates Bacillus subtilis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.20 105000
-
 gel filtration Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.20 meso-2,6-Diaminoheptanedioate Bacillus subtilis lysine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.20 Bacillus subtilis
-
-
-
4.1.1.20 Brevibacterium sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Bacillus subtilis L-Lysine + CO2
-
 ?
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Brevibacterium sp. L-Lysine + CO2
-
 ?
4.1.1.20 meso-2,6-Diaminoheptanedioate lysine biosynthesis Bacillus subtilis ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.20 25
-
 enzyme assay at Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.20 8.5
-
-
 Bacillus subtilis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.20 7.5 9 more than half-maximal activity between 7.5 and pH 9.0 Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.20 pyridoxal 5'-phosphate Km: 0.002 mM Bacillus subtilis