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Literature summary extracted from
- Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by a alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites (1992), J. Biol. Chem., 267, 150-158.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.17 | expression in Escherichia coli | Mus musculus |
| 4.1.1.17 | wild type and mutant enzymes C360A, K69A, and C70S | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.17 | alpha-DL-difluoromethylornithine | irreversibel; mechanism of irreversible inactivation | Mus musculus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.17 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.17 | L-Orn | - |
Mus musculus | Putrescine + CO2 | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.17 | pyridoxal 5'-phosphate | bound to Lys69 | Mus musculus | |
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Release 2023.1 (January 2023)
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