Literature summary extracted from

Wilkinson, S.R.; Taylor, M.C.; Touitha, S.; Mauricio, I.L.; Meyer, D.J.; Kelly, J.M.
TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum (2002), Biochem. J., 364, 787-794.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.11.1.9	expression in Escherichia coli	Trypanosoma cruzi

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.11.1.9	0.007	-	linolenic acid hydroperoxide	-	Trypanosoma cruzi

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.11.1.9	endoplasmic reticulum	co-localization with BiP	Trypanosoma cruzi	5783	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.11.1.9	glutathione + ROOH	Trypanosoma cruzi	-	glutathione disulfide + ROH + H2O	-	?
1.11.1.9	linolenic acid hydroperoxide + GSH	Trypanosoma cruzi	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.11.1.9	Trypanosoma cruzi	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.11.1.9	-	Trypanosoma cruzi

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.11.1.9	0.13	-	linolenic acid hydroperoxide	Trypanosoma cruzi
1.11.1.9	0.16	-	L-alpha-phosphatidylcholine hydroperoxide	Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.11.1.9	glutathione + ROOH	-	Trypanosoma cruzi	glutathione disulfide + ROH + H2O	-	?
1.11.1.9	L-alpha-phosphatidylcholine hydroperoxide + GSH	-	Trypanosoma cruzi	?	-	?
1.11.1.9	linolenic acid hydroperoxide + GSH	-	Trypanosoma cruzi	?	-	?

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Release 2023.1 (January 2023)